Polymeric delivery of therapeutic nucleic acids
R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …
Naturally and synthetic smart composite biomaterials for tissue regeneration
The development of smart biomaterials for tissue regeneration has become the focus of
intense research interest. More opportunities are available by the composite approach of …
intense research interest. More opportunities are available by the composite approach of …
Protein‐based Nanoparticles: from Drug Delivery to Imaging, Nanocatalysis and Protein Therapy
J Kaltbeitzel, PR Wich - Angewandte Chemie International …, 2023 - Wiley Online Library
Proteins and enzymes are versatile biomaterials for a wide range of medical applications
due to their high specificity for receptors and substrates, high degradability, low toxicity, and …
due to their high specificity for receptors and substrates, high degradability, low toxicity, and …
Lignin nanotubes as vehicles for gene delivery into human cells
Lignin nanotubes (LNTs) synthesized from the aromatic plant cell wall polymer lignin in a
sacrificial alumina membrane template have as useful features their flexibility, ease of …
sacrificial alumina membrane template have as useful features their flexibility, ease of …
Site-selective protein modification with polymers for advanced biomedical applications
X Liu, J Sun, W Gao - Biomaterials, 2018 - Elsevier
Protein modification with polymers has led to intriguing and new types of bioconjugates.
They combine the tunable physicochemical properties of the polymers with the specific …
They combine the tunable physicochemical properties of the polymers with the specific …
Protein–polymer therapeutics: a macromolecular perspective
The development of protein–polymer hybrids emerged several decades ago with the vision
that their synergistic combination will offer macromolecular hybrids with manifold features to …
that their synergistic combination will offer macromolecular hybrids with manifold features to …
Co-delivery of SOX9 genes and anti-Cbfa-1 siRNA coated onto PLGA nanoparticles for chondrogenesis of human MSCs
SY Jeon, JS Park, HN Yang, DG Woo, KH Park - Biomaterials, 2012 - Elsevier
Some genes expressed in stem cells interrupt and/or enhance differentiation. Therefore, the
aim of this study was to inhibit the expression of unnecessary genes and enhance the …
aim of this study was to inhibit the expression of unnecessary genes and enhance the …
Site-selective in situ growth-induced self-assembly of protein–polymer conjugates into pH-responsive micelles for tumor microenvironment triggered fluorescence …
Self-assembly of site-selective protein–polymer conjugates into stimuli-responsive micelles
is interesting owing to their potential biomedical applications, ranging from molecular …
is interesting owing to their potential biomedical applications, ranging from molecular …
Utilizing cell–matrix interactions to modulate gene transfer to stem cells inside hyaluronic acid hydrogels
S Gojgini, T Tokatlian, T Segura - Molecular pharmaceutics, 2011 - ACS Publications
The effective delivery of DNA locally would increase the applicability of gene therapy in
tissue regeneration, where diseased tissue is to be repaired in situ. One promising approach …
tissue regeneration, where diseased tissue is to be repaired in situ. One promising approach …
PEGylated albumin-based polyion complex micelles for protein delivery
An increasing amount of therapeutic agents are based on proteins. However, proteins as
drug have intrinsic problems such as their low hydrolytic stability. Delivery of proteins using …
drug have intrinsic problems such as their low hydrolytic stability. Delivery of proteins using …