Polymeric delivery of therapeutic nucleic acids

R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Naturally and synthetic smart composite biomaterials for tissue regeneration

RA Perez, JE Won, JC Knowles, HW Kim - Advanced drug delivery reviews, 2013 - Elsevier
The development of smart biomaterials for tissue regeneration has become the focus of
intense research interest. More opportunities are available by the composite approach of …

Protein‐based Nanoparticles: from Drug Delivery to Imaging, Nanocatalysis and Protein Therapy

J Kaltbeitzel, PR Wich - Angewandte Chemie International …, 2023 - Wiley Online Library
Proteins and enzymes are versatile biomaterials for a wide range of medical applications
due to their high specificity for receptors and substrates, high degradability, low toxicity, and …

Lignin nanotubes as vehicles for gene delivery into human cells

E Ten, C Ling, Y Wang, A Srivastava… - …, 2014 - ACS Publications
Lignin nanotubes (LNTs) synthesized from the aromatic plant cell wall polymer lignin in a
sacrificial alumina membrane template have as useful features their flexibility, ease of …

Site-selective protein modification with polymers for advanced biomedical applications

X Liu, J Sun, W Gao - Biomaterials, 2018 - Elsevier
Protein modification with polymers has led to intriguing and new types of bioconjugates.
They combine the tunable physicochemical properties of the polymers with the specific …

Protein–polymer therapeutics: a macromolecular perspective

Y Wu, DYW Ng, SL Kuan, T Weil - Biomaterials science, 2015 - pubs.rsc.org
The development of protein–polymer hybrids emerged several decades ago with the vision
that their synergistic combination will offer macromolecular hybrids with manifold features to …

Co-delivery of SOX9 genes and anti-Cbfa-1 siRNA coated onto PLGA nanoparticles for chondrogenesis of human MSCs

SY Jeon, JS Park, HN Yang, DG Woo, KH Park - Biomaterials, 2012 - Elsevier
Some genes expressed in stem cells interrupt and/or enhance differentiation. Therefore, the
aim of this study was to inhibit the expression of unnecessary genes and enhance the …

Site-selective in situ growth-induced self-assembly of protein–polymer conjugates into pH-responsive micelles for tumor microenvironment triggered fluorescence …

P Li, M Sun, Z Xu, X Liu, W Zhao, W Gao - Biomacromolecules, 2018 - ACS Publications
Self-assembly of site-selective protein–polymer conjugates into stimuli-responsive micelles
is interesting owing to their potential biomedical applications, ranging from molecular …

Utilizing cell–matrix interactions to modulate gene transfer to stem cells inside hyaluronic acid hydrogels

S Gojgini, T Tokatlian, T Segura - Molecular pharmaceutics, 2011 - ACS Publications
The effective delivery of DNA locally would increase the applicability of gene therapy in
tissue regeneration, where diseased tissue is to be repaired in situ. One promising approach …

PEGylated albumin-based polyion complex micelles for protein delivery

Y Jiang, H Lu, F Chen, M Callari… - …, 2016 - ACS Publications
An increasing amount of therapeutic agents are based on proteins. However, proteins as
drug have intrinsic problems such as their low hydrolytic stability. Delivery of proteins using …