Here, we review the current state of the art in analytical and structural methods used to
characterize therapeutic monoclonal antibodies (mAbs) and derivatives. First, a general …

Targeted mass spectrometry (MS) is becoming widely used in academia and in
pharmaceutical and biotechnology industries for sensitive and quantitative detection of …

Diffuse intrinsic pontine glioma (DIPG) remains a fatal brainstem tumor demanding
innovative therapies. As B7-H3 (CD276) is expressed on central nervous system (CNS) …

Adoption of targeted mass spectrometry (MS) approaches such as multiple reaction
monitoring (MRM) to study biological and biomedical questions is well underway in the …

Cancer genomics research aims to advance personalized oncology by finding and targeting
specific genetic alterations associated with cancers. In genome-driven oncology, treatments …

Comprehensive, high throughput analysis of the plasma proteome has the potential to
enable holistic analysis of the health state of an individual. Based on our own experience …

BACKGROUND For many years, basic and clinical researchers have taken advantage of the
analytical sensitivity and specificity afforded by mass spectrometry in the measurement of …

Recent advances in the proteomics field have allowed a series of high throughput
experiments to be conducted on chloroplast samples, and the data are available in several …

The purpose of this study was to determine the protein amounts of blood–brain barrier (BBB)
permeability-related transporters, receptors, and tight junction proteins in Sprague Dawley …

This Feature will introduce the strategies of therapeutic antibodies (mAbs) in-depth
characterization by mass spectrometry (MS) and discuss analytical comparison of biosimilar …