Glutamate is the brain's main excitatory neurotransmitter. Glutamatergic neurons primarily
compose basic neuronal networks, especially in the cortex. An imbalance of excitatory and …

Alzheimer's disease and epilepsy are common nervous system diseases in older adults, and
their incidence rates tend to increase with age. Patients with mild cognitive impairment and …

Introduction The prescription patterns of antiseizure medication (ASM) are subject to new
scientific evidence and sociodemographic and practical aspects. This study analyzed trends …

Background In randomized controlled trials, add-on brivaracetam (BRV) reduced seizure
frequency in patients with drug-resistant focal epilepsy. Studies performed in a naturalistic …

This retrospective study assessed long‐term effectiveness of add‐on perampanel (PER) in
patients with Lennox–Gastaut syndrome (LGS). Outcomes included time to PER failure and …

The posterior cingulate cortex, a key hub of the default mode network, underlies
autobiographical memory retrieval and displays hypometabolic changes early in Alzheimer …

(1) Background: Epilepsy is a frequent comorbidity in patients with brain tumors, in whom
seizures are often drug-resistant. Current evidence suggests that excess of glutamatergic …

There is a paucity of literature regarding the optimal selection of combination antiseizure
medications (ASMs) for drug‐resistant epilepsy (DRE). The aim of this scoping review is to …

Introduction In randomized controlled trials, add-on brivaracetam (BRV) reduced seizure
frequency in patients with drug-resistant focal epilepsy. Most real-world research on BRV …

Objective The main aim of this study was to assess the efficacy, safety, and tolerability of
adjunctive perampanel (PER) in the treatment of children and adolescents with epilepsy …