[HTML][HTML] The broad-spectrum activity of perampanel: state of the art and future perspective of AMPA antagonism beyond epilepsy
F Perversi, C Costa, A Labate, S Lattanzi… - Frontiers in …, 2023 - frontiersin.org
Glutamate is the brain's main excitatory neurotransmitter. Glutamatergic neurons primarily
compose basic neuronal networks, especially in the cortex. An imbalance of excitatory and …
compose basic neuronal networks, especially in the cortex. An imbalance of excitatory and …
[HTML][HTML] The clinical correlation between Alzheimer's disease and epilepsy
D Zhang, S Chen, S Xu, J Wu, Y Zhuang, W Cao… - Frontiers in …, 2022 - frontiersin.org
Alzheimer's disease and epilepsy are common nervous system diseases in older adults, and
their incidence rates tend to increase with age. Patients with mild cognitive impairment and …
their incidence rates tend to increase with age. Patients with mild cognitive impairment and …
Trends in antiseizure medication prescription patterns among all adults, women, and older adults with epilepsy: A German longitudinal analysis from 2008 to 2020
Introduction The prescription patterns of antiseizure medication (ASM) are subject to new
scientific evidence and sociodemographic and practical aspects. This study analyzed trends …
scientific evidence and sociodemographic and practical aspects. This study analyzed trends …
[HTML][HTML] Adjunctive brivaracetam in focal epilepsy: real-world evidence from the BRIVAracetam add-on First Italian netwoRk STudy (BRIVAFIRST)
S Lattanzi, L Canafoglia, MP Canevini, S Casciato… - CNS drugs, 2021 - Springer
Background In randomized controlled trials, add-on brivaracetam (BRV) reduced seizure
frequency in patients with drug-resistant focal epilepsy. Studies performed in a naturalistic …
frequency in patients with drug-resistant focal epilepsy. Studies performed in a naturalistic …
Long‐term effectiveness of add‐on perampanel in patients with Lennox–Gastaut syndrome: A multicenter retrospective study
S Matricardi, E Cesaroni, P Bonanni, N Foschi… - …, 2023 - Wiley Online Library
This retrospective study assessed long‐term effectiveness of add‐on perampanel (PER) in
patients with Lennox–Gastaut syndrome (LGS). Outcomes included time to PER failure and …
patients with Lennox–Gastaut syndrome (LGS). Outcomes included time to PER failure and …
Posterior cingulate cortex reveals an expression profile of resilience in cognitively intact elders
CM Kelley, SD Ginsberg, WS Liang… - Brain …, 2022 - academic.oup.com
The posterior cingulate cortex, a key hub of the default mode network, underlies
autobiographical memory retrieval and displays hypometabolic changes early in Alzheimer …
autobiographical memory retrieval and displays hypometabolic changes early in Alzheimer …
[HTML][HTML] Efficacy and tolerability of perampanel in brain tumor-related epilepsy: a systematic review
(1) Background: Epilepsy is a frequent comorbidity in patients with brain tumors, in whom
seizures are often drug-resistant. Current evidence suggests that excess of glutamatergic …
seizures are often drug-resistant. Current evidence suggests that excess of glutamatergic …
Scoping review of rational polytherapy in patients with drug‐resistant epilepsy
MKS Grinalds, C Yoder, Z Krauss… - … : The Journal of …, 2023 - Wiley Online Library
There is a paucity of literature regarding the optimal selection of combination antiseizure
medications (ASMs) for drug‐resistant epilepsy (DRE). The aim of this scoping review is to …
medications (ASMs) for drug‐resistant epilepsy (DRE). The aim of this scoping review is to …
[HTML][HTML] Brivaracetam as early add-on treatment in patients with focal seizures: a retrospective, multicenter, real-world study
S Lattanzi, L Canafoglia, MP Canevini, S Casciato… - Neurology and …, 2022 - Springer
Introduction In randomized controlled trials, add-on brivaracetam (BRV) reduced seizure
frequency in patients with drug-resistant focal epilepsy. Most real-world research on BRV …
frequency in patients with drug-resistant focal epilepsy. Most real-world research on BRV …
[HTML][HTML] Effectiveness and tolerability of adjunctive perampanel in the treatment of pediatric patients with uncontrolled epilepsy: a retrospective, single-center, real …
L Gao, L Shi, Q Liu - Epilepsy & Behavior, 2022 - Elsevier
Objective The main aim of this study was to assess the efficacy, safety, and tolerability of
adjunctive perampanel (PER) in the treatment of children and adolescents with epilepsy …
adjunctive perampanel (PER) in the treatment of children and adolescents with epilepsy …