Skeletal metastases are frequent complications of many cancers, causing bone
complications (fractures, bone pain, disability) that negatively affect the patient's quality of …

Osteosarcoma, the most common malignant tumor of the bone, seriously influences people's
lives and increases their economic burden. Conventional chemotherapy drugs achieve …

A variety of targeted nanoparticles were developed for the diagnosis and therapy of
orthotopic and metastatic bone tumors during the past decade. This critical review will focus …

Bone diseases including osteoarthritis, osteoporosis, and bone tumors are becoming severe
threats to public health. Bone-targeted biomaterials-based strategies could improve …

Bone is a preferential site for cancer metastases, including multiple myeloma, prostate, and
breast cancers. The composition of bone, especially the extracellular matrix (ECM), make it …

In addition to reducing fracture risk, zoledronic acid has been found in some studies to
decrease mortality in humans and extend lifespan and healthspan in animals. Because …

Metastasis is a complex systemic disease that develops as a result of interactions between
tumor cells and their local and distant microenvironments. Local and systemic immune …

Clinical tumor dormancy is specified as an extended latency period between removal of the
primary tumor and subsequent relapse in a cancer patient who has been clinically disease …

Polysaccharide is one of main components in Polygonatum sibiricum (PS), which is an
herbal medicine widely used in East Asia. Polysaccharides from Polygonatum sibiricum has …

Numerous preclinical studies have reported a pro-tumour role for granulocyte colony-
stimulating factor (G-CSF) that is predominantly mediated by neutrophils and MDSCs, the …