Dysfunctional vascular endothelium as a driver of atherosclerosis: emerging insights into pathogenesis and treatment
Atherosclerosis, the chronic accumulation of cholesterol-rich plaque within arteries, is
associated with a broad spectrum of cardiovascular diseases including myocardial …
associated with a broad spectrum of cardiovascular diseases including myocardial …
The AP-1 transcriptional complex: Local switch or remote command?
F Bejjani, E Evanno, K Zibara, M Piechaczyk… - … et Biophysica Acta (BBA …, 2019 - Elsevier
The ubiquitous family of AP-1 dimeric transcription complexes is involved in virtually all
cellular and physiological functions. It is paramount for cells to reprogram gene expression …
cellular and physiological functions. It is paramount for cells to reprogram gene expression …
HMOX1 upregulation promotes ferroptosis in diabetic atherosclerosis
Objective Atherosclerotic vascular disease remains the principal cause of death and
disability among patients with type 2 diabetes. Unfortunately, the problem is not adequately …
disability among patients with type 2 diabetes. Unfortunately, the problem is not adequately …
Genome-wide analysis identifies novel susceptibility loci for myocardial infarction
Aims While most patients with myocardial infarction (MI) have underlying coronary
atherosclerosis, not all patients with coronary artery disease (CAD) develop MI. We sought …
atherosclerosis, not all patients with coronary artery disease (CAD) develop MI. We sought …
AP-1 transcription factors and the BAF complex mediate signal-dependent enhancer selection
Enhancer elements are genomic regulatory sequences that direct the selective expression
of genes so that genetically identical cells can differentiate and acquire the highly …
of genes so that genetically identical cells can differentiate and acquire the highly …
Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells
Vascular endothelial cell (EC) function depends on appropriate organ-specific molecular
and cellular specializations. To explore genomic mechanisms that control this specialization …
and cellular specializations. To explore genomic mechanisms that control this specialization …
Single-cell epigenomics and functional fine-mapping of atherosclerosis GWAS loci
T Örd, K Õunap, LK Stolze, R Aherrahrou… - Circulation …, 2021 - Am Heart Assoc
Rationale: Genome-wide association studies have identified hundreds of loci associated
with coronary artery disease (CAD). Many of these loci are enriched in cisregulatory …
with coronary artery disease (CAD). Many of these loci are enriched in cisregulatory …
The transcription factor ERG regulates super-enhancers associated with an endothelial-specific gene expression program
V Kalna, Y Yang, CR Peghaire, K Frudd… - Circulation …, 2019 - Am Heart Assoc
Rationale: The ETS (E-26 transformation-specific) transcription factor ERG (ETS-related
gene) is essential for endothelial homeostasis, driving expression of lineage genes and …
gene) is essential for endothelial homeostasis, driving expression of lineage genes and …
Regulation of CCL2 expression in human vascular endothelial cells by a neighboring divergently transcribed long noncoding RNA
N Khyzha, M Khor, PV DiStefano… - Proceedings of the …, 2019 - National Acad Sciences
Atherosclerosis is a chronic inflammatory disease that is driven, in part, by activation of
vascular endothelial cells (ECs). In response to inflammatory stimuli, the nuclear factor …
vascular endothelial cells (ECs). In response to inflammatory stimuli, the nuclear factor …
Genetic regulatory mechanisms of smooth muscle cells map to coronary artery disease risk loci
Coronary artery disease (CAD) is the leading cause of death globally. Genome-wide
association studies (GWASs) have identified more than 95 independent loci that influence …
association studies (GWASs) have identified more than 95 independent loci that influence …