The ability to split one cell into two is fundamental to all life, and many bacteria can
accomplish this feat several times per hour with high accuracy. Most bacteria call on an …

Cell division in Streptococcus pneumoniae (pneumococcus) is performed and regulated by
a protein complex consisting of at least 14 different protein elements; known as the …

As bacteria proliferate, DNA replication, chromosome segregation, cell wall synthesis, and
cytokinesis occur concomitantly and need to be tightly regulated and coordinated. Although …

Combating anti-microbial resistance by developing alternative strategies is the need of the
hour. Cell division, particularly FtsZ, is being extensively studied for its potential as an …

CRISPR interference (CRISPRi) and CRISPR activation (CRISPRa) have become
ubiquitous approaches to control gene expression in bacteria due to their simple design and …

The bacterial cell envelope consists of multiple layers, including the peptidoglycan cell wall,
one or two membranes, and often an external layer composed of capsular polysaccharides …

The bacterial FtsZ-ring initiates division by recruiting a large repertoire of proteins (the
divisome; Z-ring) needed for septation and separation of cells. Although FtsZ is essential …

The spheroid bacterium Staphylococcus aureus is often used as a model of morphogenesis
due to its apparently simple cell cycle. S. aureus has many cell division proteins that are …

Streptococcus pneumoniae (Spn) strains cause pneumonia that kills millions every year
worldwide. Spn produces Ply, a hemolysin that lyses erythrocytes releasing hemoglobin …

Several vaccines targeting bacterial pathogens show reduced efficacy upon concurrent viral
infection, indicating that a new vaccinology approach is required. To identify antigens for the …