DNA methylation inhibitors in cancer: recent and future approaches
This review presents the different human DNA methyltransferases (DNMTs), their biological
roles, their mechanisms of action and their role in cancer. The description of assays for …
roles, their mechanisms of action and their role in cancer. The description of assays for …
Radical Cascade Reactions of β, γ‐Unsaturated Hydrazones/Oximes
YF Si, QY Lv, B Yu - Advanced Synthesis & Catalysis, 2021 - Wiley Online Library
Radical cascade cyclization of β, γ‐unsaturated hydrazones/oximes has recently emerged
as an efficient and powerful protocol for the construction of diverse and valuable …
as an efficient and powerful protocol for the construction of diverse and valuable …
Catalytic enantioselective iodoetherification of oximes
CB Tripathi, S Mukherjee - Angewandte Chemie, 2013 - Wiley Online Library
Heterodifunctionalization of unactivated olefins continues to be an attractive and widely
utilized strategy for the generation of densely functionalized organic molecules. Electrophilic …
utilized strategy for the generation of densely functionalized organic molecules. Electrophilic …
Copper-catalyzed oxidative oxyamination/diamination of internal alkenes of unsaturated oximes with simple amines
RH Liu, D Wei, B Han, W Yu - ACS Catalysis, 2016 - ACS Publications
A convenient and versatile oxidative intra/intermolecular oxyamination and diamination of
unactivated alkenes has been developed through copper-catalyzed radical reactions of β, γ …
unactivated alkenes has been developed through copper-catalyzed radical reactions of β, γ …
[HTML][HTML] Recent progress in DNA methyltransferase inhibitors as anticancer agents
Z Zhang, G Wang, Y Li, D Lei, J Xiang… - Frontiers in …, 2022 - frontiersin.org
DNA methylation mediated by DNA methyltransferase is an important epigenetic process
that regulates gene expression in mammals, which plays a key role in silencing certain …
that regulates gene expression in mammals, which plays a key role in silencing certain …
Targeting DNA methylation with small molecules: what's next? Miniperspective
A Erdmann, L Halby, J Fahy… - Journal of medicinal …, 2015 - ACS Publications
DNA methylation is a mammalian epigenetic mark that is involved in defining where and
when genes are expressed, both in normal cells and in the context of diseases. Like other …
when genes are expressed, both in normal cells and in the context of diseases. Like other …
Electrochemical Chalcogenation of β,γ‐Unsaturated Amides and Oximes to Corresponding Oxazolines and Isoxazolines
The current report represents a transition‐metal‐free synthesis of oxazoline and isoxazoline
derivatives by a tandem electro‐oxidative chalcogenation‐cyclization process. Both C− Se …
derivatives by a tandem electro‐oxidative chalcogenation‐cyclization process. Both C− Se …
DNA methyltransferase inhibitors in cancer: from pharmacology to translational studies
D Pechalrieu, C Etievant, PB Arimondo - Biochemical pharmacology, 2017 - Elsevier
DNA methylation is a mammalian epigenetic mark that participates to define where and
when genes are expressed, both in normal cells and in the context of diseases. Like other …
when genes are expressed, both in normal cells and in the context of diseases. Like other …
[HTML][HTML] DNA methylation targeting: the DNMT/HMT crosstalk challenge
O Castillo-Aguilera, P Depreux, L Halby, PB Arimondo… - Biomolecules, 2017 - mdpi.com
Chromatin can adopt a decondensed state linked to gene transcription (euchromatin) and a
condensed state linked to transcriptional repression (heterochromatin). These states are …
condensed state linked to transcriptional repression (heterochromatin). These states are …
Enantioselective Synthesis of Isoxazolines Enabled by Palladium‐Catalyzed Carboetherification of Alkenyl Oximes
Reported here is a highly efficient Pd/Xiang‐Phos catalyzed enantioselective
carboetherification of alkenyl oximes with either aryl or alkenyl halides, delivering various …
carboetherification of alkenyl oximes with either aryl or alkenyl halides, delivering various …