As the incidence of hepatobiliary diseases increases, we must improve our understanding of
the molecular, cellular, and physiological factors that contribute to the pathogenesis of liver …

Endoplasmic reticulum (ER) stress is easily observed in chronic liver disease, which often
causes accumulation of unfolded or misfolded proteins in the ER, leading to unfolded …

Since its debut in the biomedical research fields in 1981, zebrafish have been used as a
vertebrate model organism in more than 40,000 biomedical research studies. Especially …

Exessive drinking is commonly associated with a wide spectrum of liver injuries. The term
alcoholic liver disease (ALD) is generally used to refer to this spectrum of hepatic …

Background Liver is a vital organ responsible for metabolizing and detoxifying both
endogenous and exogenous substances in the body. However, it is susceptible to damage …

Aims Alcoholic liver disease (ALD) is a leading health risk worldwide, which can induce
hepatic steatosis, progressive fibrosis, cirrhosis and even carcinoma. As a potential …

Exploring the etiology of liver injury is critical to fundamental science and precise treatment,
which has not yet been achieved by molecule imaging techniques. Herein, we manage to …

Nonalcoholic fatty liver disease (NAFLD), the accumulation of lipid within hepatocytes, is
increasing in prevalence. Increasing fructose consumption correlates with this increased …

The mechanisms underlying liver fibrosis are multifaceted and remain elusive with no
approved antifibrotic treatments available. The adult zebrafish has been an underutilized …

Background Non-alcoholic fatty liver disease (NAFLD), characterized as excessive lipid
accumulation within hepatocytes, is growing in prevalence. The exploitation of effective …