Breaking TADs: how alterations of chromatin domains result in disease
Spatial organization is an inherent property of the vertebrate genome to accommodate the
roughly 2m of DNA in the nucleus of a cell. In this nonrandom organization, topologically …
roughly 2m of DNA in the nucleus of a cell. In this nonrandom organization, topologically …
Genomic views of distant-acting enhancers
In contrast to protein-coding sequences, the significance of variation in non-coding DNA in
human disease has been minimally explored. A great number of recent genome-wide …
human disease has been minimally explored. A great number of recent genome-wide …
Enhancer redundancy provides phenotypic robustness in mammalian development
M Osterwalder, I Barozzi, V Tissières… - Nature, 2018 - nature.com
Distant-acting tissue-specific enhancers, which regulate gene expression, vastly outnumber
protein-coding genes in mammalian genomes, but the functional importance of this …
protein-coding genes in mammalian genomes, but the functional importance of this …
[HTML][HTML] An atlas of dynamic chromatin landscapes in mouse fetal development
Abstract The Encyclopedia of DNA Elements (ENCODE) project has established a genomic
resource for mammalian development, profiling a diverse panel of mouse tissues at 8 …
resource for mammalian development, profiling a diverse panel of mouse tissues at 8 …
[HTML][HTML] Progressive loss of function in a limb enhancer during snake evolution
The evolution of body shape is thought to be tightly coupled to changes in regulatory
sequences, but specific molecular events associated with major morphological transitions in …
sequences, but specific molecular events associated with major morphological transitions in …
Modulation of tissue repair by regeneration enhancer elements
How tissue regeneration programs are triggered by injury has received limited research
attention. Here we investigate the existence of enhancer regulatory elements that are …
attention. Here we investigate the existence of enhancer regulatory elements that are …
[HTML][HTML] The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis
S Wang, AB Aurora, BA Johnson, X Qi, J McAnally… - Developmental cell, 2008 - cell.com
Endothelial cells play essential roles in maintenance of vascular integrity, angiogenesis, and
wound repair. We show that an endothelial cell-restricted microRNA (miR-126) mediates …
wound repair. We show that an endothelial cell-restricted microRNA (miR-126) mediates …
[HTML][HTML] Rapid and pervasive changes in genome-wide enhancer usage during mammalian development
Enhancers are distal regulatory elements that can activate tissue-specific gene expression
and are abundant throughout mammalian genomes. Although substantial progress has …
and are abundant throughout mammalian genomes. Although substantial progress has …
VISTA Enhancer Browser—a database of tissue-specific human enhancers
Despite the known existence of distant-acting cis-regulatory elements in the human genome,
only a small fraction of these elements has been identified and experimentally characterized …
only a small fraction of these elements has been identified and experimentally characterized …
Evolutionary changes in promoter and enhancer activity during human corticogenesis
Human higher cognition is attributed to the evolutionary expansion and elaboration of the
human cerebral cortex. However, the genetic mechanisms contributing to these …
human cerebral cortex. However, the genetic mechanisms contributing to these …