▪ Abstract The aim of this review is to provide a basic framework for understanding the
function of mammalian transient receptor potential (TRP) channels, particularly as they have …

The endothelium functions as a semipermeable barrier regulating tissue fluid homeostasis
and transmigration of leukocytes and providing essential nutrients across the vessel wall …

The TRP (“transient receptor potential”) family of ion channels now comprises more than 30
cation channels, most of which are permeable for Ca2+, and some also for Mg2+. On the …

Progressive kidney failure is a genetically and clinically heterogeneous group of disorders.
Podocyte foot processes and the interposed glomerular slit diaphragm are essential …

Podocytes of the renal glomerulus are unique cells with a complex cellular organization
consisting of a cell body, major processes and foot processes. Podocyte foot processes form …

The pulmonary circulation is a low-resistance, low-pressure, and high-compliance system
that allows the lungs to receive the entire cardiac output. Pulmonary arterial pressure is a …

Pulmonary hypertension is a complex, progressive condition arising from a variety of genetic
and pathogenic causes. Patients present with a spectrum of histologic and …

Mast cell mediator release represents a pivotal event in the initiation of inflammatory
reactions associated with allergic disorders. These responses follow antigen‐mediated …

Angiotensin (Ang) II participates in the pathogenesis of heart failure through induction of
cardiac hypertrophy. Ang II‐induced hypertrophic growth of cardiomyocytes is mediated by …

The existence of a mammalian family of TRPC ion channels, direct homologues of TRP, the
visual transduction channel of flies, was discovered during 1995–1996 as a consequence of …