Ultrasound-based micro-/nanosystems for biomedical applications

H Huang, Y Zheng, M Chang, J Song, L Xia… - Chemical …, 2024 - ACS Publications
Due to the intrinsic non-invasive nature, cost-effectiveness, high safety, and real-time
capabilities, besides diagnostic imaging, ultrasound as a typical mechanical wave has been …

Blood-brain barrier disruption: a culprit of cognitive decline?

J Che, Y Sun, Y Deng, J Zhang - Fluids and Barriers of the CNS, 2024 - Springer
Cognitive decline covers a broad spectrum of disorders, not only resulting from brain
diseases but also from systemic diseases, which seriously influence the quality of life and …

[HTML][HTML] Ultrasound blood–brain barrier opening and aducanumab in Alzheimer's disease

AR Rezai, PF D'Haese, V Finomore… - … England Journal of …, 2024 - Mass Medical Soc
Antiamyloid antibodies have been used to reduce cerebral amyloid-beta (Aβ) load in
patients with Alzheimer's disease. We applied focused ultrasound with each of six monthly …

First-in-human prospective trial of sonobiopsy in high-grade glioma patients using neuronavigation-guided focused ultrasound

J Yuan, L Xu, CY Chien, Y Yang, Y Yue… - NPJ Precision …, 2023 - nature.com
Sonobiopsy is an emerging technology that combines focused ultrasound (FUS) with
microbubbles to enrich circulating brain disease-specific biomarkers for noninvasive …

Blood–brain barrier alterations and their impact on Parkinson's disease pathogenesis and therapy

K Lau, R Kotzur, F Richter - Translational neurodegeneration, 2024 - Springer
There is increasing evidence for blood–brain barrier (BBB) alterations in Parkinson's
disease (PD), the second most common neurodegenerative disorder with rapidly rising …

Low-intensity focused ultrasound targeting the nucleus accumbens as a potential treatment for substance use disorder: safety and feasibility clinical trial

JJ Mahoney, MW Haut, J Carpenter, M Ranjan… - Frontiers in …, 2023 - frontiersin.org
Introduction While current treatments for substance use disorder (SUD) are beneficial,
success rates remain low and treatment outcomes are complicated by co-occurring SUDs …

Compressive stresses in cancer: characterization and implications for tumour progression and treatment

JA Linke, LL Munn, RK Jain - Nature Reviews Cancer, 2024 - nature.com
Beyond their many well-established biological aberrations, solid tumours create an
abnormal physical microenvironment that fuels cancer progression and confers treatment …

Exploiting the mechanical effects of ultrasound for noninvasive therapy

MA O'Reilly - Science, 2024 - science.org
Focused ultrasound is a platform technology capable of eliciting a wide range of biological
responses with high spatial precision deep within the body. Although focused ultrasound is …

The road ahead to successful BBB opening and drug-delivery with focused ultrasound

M López-Aguirre, M Castillo-Ortiz… - Journal of Controlled …, 2024 - Elsevier
This review delves into the innovative technology of Blood-Brain Barrier (BBB) opening with
low-intensity focused ultrasound in combination with microbubbles (LIFU-MB), a promising …

Ultrasound-mediated blood–brain barrier opening uncovers an intracerebral perivenous fluid network in persons with Alzheimer's disease

RI Mehta, JS Carpenter, RI Mehta, MW Haut… - Fluids and Barriers of …, 2023 - Springer
Background Focused ultrasound (FUS)-mediated blood–brain barrier (BBB) opening is
under investigation as a therapeutic modality for neurodegeneration, yet its effects in …