Citrate plays a central role in cancer cells' metabolism and regulation. Derived from
mitochondrial synthesis and/or carboxylation of α-ketoglutarate, it is cleaved by ATP-citrate …

Fructose consumption is linked to the rising incidence of obesity and cancer, which are two
of the leading causes of morbidity and mortality globally,. Dietary fructose metabolism …

Emerging evidence suggests that metabolic adaptation is a vital hallmark and prerequisite
for macrophage phenotype transition. Pyruvate kinase M2 (PKM2) is an essential molecular …

Pyruvate kinase is a key regulator in glycolysis through the conversion of
phosphoenolpyruvate (PEP) into pyruvate. Pyruvate kinase exists in various isoforms that …

Cancer mortality is primarily a consequence of its metastatic spread. Here, we report that
methionine sulfoxide reductase A (MSRA), which can reduce oxidized methionine residues …

Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease, and the
molecular mechanisms remain poorly understood. Our findings demonstrated that pyruvate …

Compromised immunosurveillance leads to chemotherapy resistance and disease relapse
of hematological malignancies. Amino acid metabolism regulates immune responses and …

Dysregulation of deubiquitination has been reported to contribute to carcinogenesis.
However, the function and mechanism of deubiquitinating enzyme 26S proteasome non …

Metabolic reprogramming is observed across all cancer types. Indeed, the success of many
classic chemotherapies stems from their targeting of cancer metabolism. Contemporary …

Damage-associated molecular patterns (DAMPs) such as extracellular ATP and nigericin (a
bacterial toxin) not only act as potassium ion (K+) efflux inducers to activate NLRP3 …