Huntington disease (HD) can be seen as a model neurodegenerative disorder, in that it is
caused by a single genetic mutation and is amenable to predictive genetic testing, with …

Diffusion MRI enabled in vivo microstructural imaging of the fiber tracts in the brain resulting
in its application in a wide range of settings, including in neurological and neurosurgical …

Background TRACK-HD is a multinational prospective observational study of Huntington's
disease (HD) that examines clinical and biological findings of disease progression in …

Background TRACK-HD is a prospective observational study of Huntington's disease (HD)
that examines disease progression in premanifest individuals carrying the mutant HTT gene …

Objectives: To investigate the function–structure relationship of white matter within different
stages of Huntington's disease (HD) using diffusion tensor imaging (DTI). Experimental …

Objective To quantify 18-month changes in white matter microstructure in premanifest (pre-
HD) and symptomatic Huntington's disease (symp-HD). To investigate baseline clinical …

Huntington's disease (HD) results in progressive impairment of motor and cognitive function
and neuropsychiatric disturbance. There are no disease-modifying treatments available, but …

The ability to image the whole brain through ever more subtle and specific
methods/contrasts has come to play a key role in understanding the basis of brain …

Large-scale longitudinal neuroimaging studies with diffusion imaging techniques are
necessary to test and validate models of white matter neurophysiological processes that …

IMAGE-HD is an Australian based multi-modal longitudinal magnetic resonance imaging
(MRI) study in premanifest and early symptomatic Huntington's disease (pre-HD and symp …