Virulence Factors of Pseudomonas Aeruginosa and Antivirulence Strategies to Combat Its Drug Resistance

C Liao, X Huang, Q Wang, D Yao, W Lu - Frontiers in cellular and …, 2022 - frontiersin.org
Pseudomonas aeruginosa is an opportunistic pathogen causing nosocomial infections in
severely ill and immunocompromised patients. Ubiquitously disseminated in the …

Toll-like receptors in sepsis-associated cytokine storm and their endogenous negative regulators as future immunomodulatory targets

V Kumar - International immunopharmacology, 2020 - Elsevier
Cytokine storm generates during various systemic acute infections, including sepsis and
current pandemic called COVID-19 (severe) causing devastating inflammatory conditions …

Toll-like receptors in the pathogenesis of neuroinflammation

V Kumar - Journal of Neuroimmunology, 2019 - Elsevier
Toll-like receptors (TLRs) are discovered as crucial pattern recognition receptors (PRRs)
involved in the recognition of pathogen-associated molecular patterns (PAMPs). Later …

Recent clinical trends in Toll‐like receptor targeting therapeutics

MA Anwar, M Shah, J Kim, S Choi - Medicinal research reviews, 2019 - Wiley Online Library
Toll‐like receptors (TLRs) are germline‐encoded receptors that are central to innate and
adaptive immune responses. Owing to their vital role in inflammation, TLRs are rational …

Toll-like receptors and their crosstalk with other innate receptors in infection and immunity

T Kawai, S Akira - Immunity, 2011 - cell.com
Toll-like receptors (TLRs) are germline-encoded pattern recognition receptors (PRRs) that
play a central role in host cell recognition and responses to microbial pathogens. TLR …

Sertoli cell immune regulation: a double-edged sword

RL Washburn, T Hibler, G Kaur, JM Dufour - Frontiers in Immunology, 2022 - frontiersin.org
The testis must create and maintain an immune privileged environment to protect maturing
germ cells from autoimmune destruction. The establishment of this protective environment is …

Acute lower respiratory tract infection

JP Mizgerd - New England Journal of Medicine, 2008 - Mass Medical Soc
Acute lower respiratory tract infections are a major cause of death and disability, yet the
mechanisms that make such infections so virulent are not entirely understood. This review …

Expression of flagella is coincident with uropathogenic Escherichia coli ascension to the upper urinary tract

MC Lane, CJ Alteri, SN Smith… - Proceedings of the …, 2007 - National Acad Sciences
Uropathogenic Escherichia coli (UPEC) cause most uncomplicated urinary tract infections
(UTIs) in humans. Because UTIs are considered to occur in an ascending manner, flagellum …

Innate immune recognition in infectious and noninfectious diseases of the lung

B Opitz, V van Laak, J Eitel, N Suttorp - American journal of …, 2010 - atsjournals.org
Diseases of the respiratory tract are among the leading causes of death in the world
population. Increasing evidence points to a key role of the innate immune system with its …

[HTML][HTML] Deletion of TLR5 results in spontaneous colitis in mice

M Vijay-Kumar, CJ Sanders, RT Taylor… - The Journal of …, 2007 - Am Soc Clin Investig
Activation of TLRs by bacterial products results in rapid activation of genes encoding
products designed to protect the host from perturbing microbes. In the intestine, which is …