Immune checkpoint blockade in infectious diseases
The upregulation of immune checkpoint molecules, such as programmed cell death protein
1 (PD1) and cytotoxic T lymphocyte antigen 4 (CTLA4), on immune cells occurs during acute …
1 (PD1) and cytotoxic T lymphocyte antigen 4 (CTLA4), on immune cells occurs during acute …
T-cell exhaustion in chronic hepatitis B infection: current knowledge and clinical significance
Hepatitis B virus (HBV) infection is the major cause of inflammatory liver disease, of which
the clinical recovery and effective anti-viral therapy is associated with the sustained viral …
the clinical recovery and effective anti-viral therapy is associated with the sustained viral …
[HTML][HTML] T cell exhaustion during persistent viral infections
SM Kahan, EJ Wherry, AJ Zajac - Virology, 2015 - Elsevier
Although robust and highly effective anti-viral T cells contribute to the clearance of many
acute infections, viral persistence is associated with the development of functionally inferior …
acute infections, viral persistence is associated with the development of functionally inferior …
[HTML][HTML] Costimulatory and coinhibitory receptor pathways in infectious disease
J Attanasio, EJ Wherry - Immunity, 2016 - cell.com
Costimulatory and inhibitory receptors play a key role in regulating immune responses to
infections. Recent translation of knowledge about inhibitory receptors such as CTLA-4 and …
infections. Recent translation of knowledge about inhibitory receptors such as CTLA-4 and …
T‐cell exhaustion: characteristics, causes and conversion
T‐cell exhaustion is characterized by the stepwise and progressive loss of T‐cell functions
and can culminate in the physical deletion of the responding cells. Exhaustion is well …
and can culminate in the physical deletion of the responding cells. Exhaustion is well …
Enhancing SIV-specific immunity in vivo by PD-1 blockade
Chronic immunodeficiency virus infections are characterized by dysfunctional cellular and
humoral antiviral immune responses,,. As such, immune modulatory therapies that enhance …
humoral antiviral immune responses,,. As such, immune modulatory therapies that enhance …
Programmed cell death-1 contributes to the establishment and maintenance of HIV-1 latency
VA Evans, RM Van Der Sluis, A Solomon… - Aids, 2018 - journals.lww.com
Objective: In HIV-infected individuals on antiretroviral therapy (ART), latent HIV is enriched
in CD4+ T cells expressing immune checkpoint molecules, in particular programmed cell …
in CD4+ T cells expressing immune checkpoint molecules, in particular programmed cell …
The intersection of COVID-19 and cancer: signaling pathways and treatment implications
The outbreak of the novel coronavirus disease 2019 (COVID-19) caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as a serious public health …
respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as a serious public health …
CTLA-4+ PD-1− memory CD4+ T cells critically contribute to viral persistence in antiretroviral therapy-suppressed, SIV-infected rhesus macaques
CS McGary, C Deleage, J Harper, L Micci, SP Ribeiro… - Immunity, 2017 - cell.com
Antiretroviral therapy (ART) suppresses viral replication in HIV-infected individuals but does
not eliminate the reservoir of latently infected cells. Recent work identified PD-1+ follicular …
not eliminate the reservoir of latently infected cells. Recent work identified PD-1+ follicular …
Features of responding T cells in cancer and chronic infection
Ever since T cell exhaustion was initially characterized and thoroughly analyzed in the
murine LCMV model, such a functional impairment has been validated in other chronic viral …
murine LCMV model, such a functional impairment has been validated in other chronic viral …