Ten decadal advances in fungal biology leading towards human well-being

A Mapook, KD Hyde, K Hassan, BM Kemkuignou… - Fungal Diversity, 2022 - Springer
Fungi are an understudied resource possessing huge potential for developing products that
can greatly improve human well-being. In the current paper, we highlight some important …

Countercurrent separation of natural products: an update

JB Friesen, JB McAlpine, SN Chen… - Journal of natural …, 2015 - ACS Publications
This work assesses the current instrumentation, method development, and applications in
countercurrent chromatography (CCC) and centrifugal partition chromatography (CPC) …

[HTML][HTML] Fusarium: more than a node or a foot-shaped basal cell

PW Crous, L Lombard, M Sandoval-Denis, KA Seifert… - Studies in mycology, 2021 - Elsevier
Recent publications have argued that there are potentially serious consequences for
researchers in recognising distinct genera in the terminal fusarioid clade of the family …

Xanthones from fungi, lichens, and bacteria: the natural products and their synthesis

KS Masters, S Bräse - Chemical reviews, 2012 - ACS Publications
In 1961 Roberts submitted a comprehensive review in which he described the 16 naturally
occurring xanthones identified to that date, of which 5 were of fungal or lichenoid origin. 2 …

Antifungals: mechanism of action and drug resistance

R Prasad, AH Shah, MK Rawal - Yeast Membrane Transport, 2016 - Springer
There are currently few antifungals in use which show efficacy against fungal diseases.
These antifungals mostly target specific components of fungal plasma membrane or its …

Muscarine, imidazole, oxazole, and thiazole alkaloids

Z Jin - Natural product reports, 2011 - pubs.rsc.org
Covering: July 2007 to June 2010. Previous review: Nat. Prod. Rep., 2009, 26, 382–445 A
great number of structurally diverse natural products containing five-membered heterocyclic …

Discovery of kibdelomycin, a potent new class of bacterial type II topoisomerase inhibitor by chemical-genetic profiling in Staphylococcus aureus

JW Phillips, MA Goetz, SK Smith, DL Zink… - Chemistry & biology, 2011 - cell.com
Bacterial resistance to known therapeutics has led to an urgent need for new chemical
classes of antibacterial agents. To address this we have applied a Staphylococcus aureus …

Fusarium-Derived Secondary Metabolites with Antimicrobial Effects

M Xu, Z Huang, W Zhu, Y Liu, X Bai, H Zhang - Molecules, 2023 - mdpi.com
Fungal microbes are important in the creation of new drugs, given their unique genetic and
metabolic diversity. As one of the most commonly found fungi in nature, Fusarium spp. has …

Confronting the challenges of natural product-based antifungal discovery

T Roemer, D Xu, SB Singh, CA Parish, G Harris… - Chemistry & biology, 2011 - cell.com
Starting with the discovery of penicillin, the pharmaceutical industry has relied extensively
on natural products (NPs) as an unparalleled source of bioactive small molecules suitable …

Beyond ergosterol: Strategies for combatting antifungal resistance in Aspergillus fumigatus and Candida auris

R Cruz, WM Wuest - Tetrahedron, 2023 - Elsevier
Aspergillus fumigatus and Candida auris are historically problematic fungal pathogens
responsible for systemic infections and high mortality rates, especially in …