The nucleus, a genome-containing organelle eponymous of eukaryotes, is enclosed by a
double membrane continuous with the endoplasmic reticulum. The nuclear pore complex …

In eukaryotic cells, the genome is organized in the form of chromatin composed of DNA and
histones that organize and regulate gene expression. The dysregulation of chromatin …

Nuclear organisation and architecture are essential for the maintenance of genomic integrity
as well as for the epigenetic regulations and gene expression. Disruption of lamin B1, major …

Abstract Exportin-1 (XPO1), the main soluble nuclear export receptor in eukaryotic cells, is
frequently overexpressed in diffuse large B-cell lymphoma (DLBCL). A selective XPO1 …

Aim: Method: This research presents a model combining machine learning (ML) techniques
and eXplainable artificial intelligence (XAI) to predict breast cancer (BC) metastasis and …

Neuroendocrine carcinomas, such as neuroendocrine prostate cancer and small-cell lung
cancer, commonly have a poor prognosis and limited therapeutic options. We report that …

The Yes‐associated protein and its transcriptional coactivator with PDZ‐binding motif
(YAP/TAZ) are two homologous transcriptional coactivators that lie at the center of a key …

The mechanical environment is important for tumorigenesis and progression. Tumor cells
can sense mechanical signals by mechanosensitive receptors, and these mechanical …

Probing nuclear protein expression while correlating cellular behavior is crucial for
deciphering underlying causes of cellular disorders, such as tumor metastasis. Despite …

The nucleus is a central organelle of eukaryotic cells undergoing dynamic structural
changes during cellular fundamental processes such as proliferation and differentiation …