Calcitonin gene–related peptide (CGRP) is a 37-amino acid peptide found primarily in the C
and Aδ sensory fibers arising from the dorsal root and trigeminal ganglia, as well as the …

Central sensitization represents an enhancement in the function of neurons and circuits in
nociceptive pathways caused by increases in membrane excitability and synaptic efficacy as …

Neuropathic pain refers to pain that originates from pathology of the nervous system.
Diabetes, infection (herpes zoster), nerve compression, nerve trauma," channelopathies," …

Synaptic plasticity is fundamental to many neurobiological functions, including memory and
pain. Central sensitization refers to the increased synaptic efficacy established in …

Pain: Moving from Symptom Control toward Mechanism-Specific Pharmacologic
Management | Annals of Internal Medicine Advertisement ACP Online Annals of Internal …

The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …

The neurotrophin family of neurotrophic factors are well-known for their effects on neuronal
survival and growth. Over the past decade, considerable evidence has accumulated from …

Sigma () receptors, initially described as a subtype of opioid receptors, are now considered
unique receptors. Pharmacological studies have distinguished two types of receptors …

The proinflammatory cytokine interleukin-17 (IL-17) is implicated in pain regulation.
However, the synaptic mechanisms by which IL-17 regulates pain transmission are …

Peroxynitrite (PN; ONOO−) and its reactive oxygen precursor superoxide (SO; O2•−) are
critically important in the development of pain of several etiologies including pain associated …