Epithelial cells require attachment to the extracellular matrix (ECM) for survival. However,
during tumour progression and metastasis, cancerous epithelial cells must adapt to and …

Classical cadherins are the key molecules that control cell–cell adhesion. Notwithstanding
this function, it is also clear that classical cadherins are more than just the “glue” that keeps …

Epithelial tissues robustly respond to internal and external stressors via dynamic cellular
rearrangements. Cell extrusion acts as a key regulator of epithelial homeostasis by …

The epithelial adherens junction is an E-cadherin-based complex that controls tissue
integrity and is stabilized at the plasma membrane by p120-catenin (p120, also known as …

Despite the fact that loss of E-cadherin is causal to the development and progression of
invasive lobular carcinoma (ILC), options to treat this major breast cancer subtype are …

Invasive lobular breast carcinoma (ILC) is characterized by proliferative indolence and long-
term latency relapses. This study aimed to identify how disseminating ILC cells control the …

Background Despite recent advances in the diagnosis and treatment of breast cancer,
metastasis remains the main cause of death. Since migration of tumor cells is considered a …

Breast cancer, one of the leading causes of mortality and morbidity among females, is
regulated in part by diverse classes of adhesion molecules one of which is known as …

Colorectal cancer (CRC) is a common malignancy with high mortality. However, the roles of
miR-425-5p and its underlying mechanism in CRC remain unknown. Here, RT-qPCR …

Cadherin-catenin complexes are integral components of the adherens junctions crucial for
cell-cell adhesion and tissue homeostasis. Dysregulation of these complexes is linked to …