Neuroinflammation as a common feature of neurodegenerative disorders

L Guzman-Martinez, RB Maccioni, V Andrade… - Frontiers in …, 2019 - frontiersin.org
Neurodegenerative diseases share the fact that they derive from altered proteins that
undergo an unfolding process followed by formation of β-structures and a pathological …

Metabolic dysfunction in Parkinson's disease: bioenergetics, redox homeostasis and central carbon metabolism

A Anandhan, MS Jacome, S Lei… - Brain Research …, 2017 - Elsevier
The loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and the
accumulation of protein inclusions (Lewy bodies) are the pathological hallmarks of …

Protective effects of dietary flavonoids against pesticide-induced toxicity: A review

X Zeng, Z Du, X Ding, W Jiang - Trends in Food Science & Technology, 2021 - Elsevier
Background Pesticide exposure is closely associated with the incidence of various severe
diseases in humans, including immune dysfunctions, respiratory problems and …

Neuroprotective potential of crocin against malathion-induced motor deficit and neurochemical alterations in rats

L Mohammadzadeh, H Hosseinzadeh… - … Science and Pollution …, 2018 - Springer
In several epidemiological studies, an association between pesticide exposure and the
incidence of Parkinson's disease (PD) has been reported. Increasing evidence showed that …

Protective effects of coenzyme Q10 nanoparticles on dichlorvos‐induced hepatotoxicity and mitochondrial/lysosomal injury

A Eftekhari, E Ahmadian, A Azami… - Environmental …, 2018 - Wiley Online Library
Abstract Development of biocompatible antioxidant nanoparticles for xenobiotic‐induced
liver disease treatment by oral or parenteral administration is of great interest in medicine. In …

Troxerutin protects against 2, 2′, 4, 4′-tetrabromodiphenyl ether (BDE-47)-induced liver inflammation by attenuating oxidative stress-mediated NAD+-depletion

ZF Zhang, Y Zhang, SH Fan, J Zhuang… - Journal of hazardous …, 2015 - Elsevier
Abstract Emerging evidence indicates that 2, 2′, 4, 4′-tetrabromodiphenyl ether (BDE-47)
induces liver injury through enhanced ROS production and lymphocytic infiltration, which …

Troxerutin improves hepatic lipid homeostasis by restoring NAD+-depletion-mediated dysfunction of lipin 1 signaling in high-fat diet-treated mice

ZF Zhang, SH Fan, YL Zheng, J Lu, DM Wu… - Biochemical …, 2014 - Elsevier
Recent evidences suggest that NAD+ depletion leads to abnormal hepatic lipid metabolism
in high-fat diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD); however, the …

In vivo assessment of dichlorvos induced histological and biochemical impairments coupled with expression of p53 responsive apoptotic genes in the liver and kidney …

SP Trivedi, A Ratn, Y Awasthi, M Kumar… - … and Physiology Part C …, 2021 - Elsevier
Sub-lethal exposure of dichlorvos induces oxidative stress, consequent genetic instability
and apoptosis coupled with impairments in biochemical, histopathological and transcription …

Targeted elimination of intracellular reactive oxygen species using nanoparticle-like chitosan-superoxide dismutase conjugate for treatment of monoiodoacetate …

X Gao, Y Ma, G Zhang, F Tang, J Zhang, J Cao… - International Journal of …, 2020 - Elsevier
In our previous work, cationic functionalized chitosan was chemically conjugated with
superoxide dismutase (SOD) to yield a unique nanoparticle-like conjugate O-HTCC-SOD …

Effects of Dichlorvos on cardiac cells: Toxicity and molecular mechanism of action

IB Salem, M Boussabbeh, JP Da Silva, NE Saidi… - Chemosphere, 2023 - Elsevier
In this study we aimed to understand the underlying mechanism of Dichlorvos-induced
toxicity in cardiac cells. For this end, cells were treated by 170 μM of Dichlorvos (DDVP) …