Herpesviral pathogenesis stems from infection of multiple cell types including the site of
latency and cells that support lytic replication. Herpesviruses utilize distinct cellular …

As an obligate intracellular parasite, Kaposi sarcoma-associated herpesvirus (KSHV) relies
on the host cell machinery to meet its needs for survival, viral replication, production, and …

Inflammasomes are cytoplasmic sensors of foreign molecules, including pathogens, and
function to induce caspase-1 activation and IL-1β cytokine maturation. Whether such a …

Kaposi's sarcoma–associated herpesvirus (KSHV) has been implicated in the pathogenesis
of Kaposi's sarcoma (KS) and other malignancies. The cellular origin of KS has been …

Kaposi's sarcoma–associated herpesvirus (KSHV) is the causative agent of Kaposi's
sarcoma, a highly vascularized tumor originating from lymphatic endothelial cells, and of at …

Abstract The phosphatidylinositol-3-kinase (PI3K)-Akt signaling pathway regulates several
key cellular functions including protein synthesis, cell growth, glucose metabolism, and …

Carbohydrates play a pivotal role in intercellular communication processes. In particular,
glycan antigens are key for sustaining homeostasis, helping leukocytes to distinguish …

Virus entry is a complex process characterized by a sequence of events. Since the discovery
of KSHV in 1994, tremendous progress has been made in our understanding of KSHV entry …

Viruses enter host cells via several mechanisms, including endocytosis, macropinocytosis,
and phagocytosis. They can also fuse at the plasma membrane and can spread within the …

Introduction Kaposi sarcoma herpes virus (KSHV) is associated with several diseases
including Kaposi sarcoma, a form of multicentric Castleman's disease, primary effusion …