Melatonin and inflammation—Story of a double‐edged blade

R Hardeland - Journal of pineal research, 2018 - Wiley Online Library
Melatonin is an immune modulator that displays both pro‐and anti‐inflammatory properties.
Proinflammatory actions, which are well documented by many studies in isolated cells or …

Melatonin and phytomelatonin: Chemistry, biosynthesis, metabolism, distribution and bioactivity in plants and animals—An overview

G Mannino, C Pernici, G Serio, C Gentile… - International Journal of …, 2021 - mdpi.com
Melatonin is a ubiquitous indolamine, largely investigated for its key role in the regulation of
several physiological processes in both animals and plants. In the last century, it was …

Oxidative stress and aging as risk factors for Alzheimer's disease and Parkinson's disease: the role of the antioxidant melatonin

J Tchekalarova, R Tzoneva - International journal of molecular sciences, 2023 - mdpi.com
Aging and neurodegenerative diseases share common hallmarks, including mitochondrial
dysfunction and protein aggregation. Moreover, one of the major issues of the demographic …

Aging, melatonin, and the pro-and anti-inflammatory networks

R Hardeland - International journal of molecular sciences, 2019 - mdpi.com
Aging and various age-related diseases are associated with reductions in melatonin
secretion, proinflammatory changes in the immune system, a deteriorating circadian system …

Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease

M Perluigi, F Di Domenico… - Physiological …, 2024 - journals.physiology.org
Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms,
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …

Defective mitophagy and synaptic degeneration in Alzheimer's disease: Focus on aging, mitochondria and synapse

H Morton, S Kshirsagar, E Orlov, LE Bunquin… - Free Radical Biology …, 2021 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
memory loss and multiple cognitive impairments. AD is marked by multiple cellular changes …

[HTML][HTML] Melatonin regulates Aβ production/clearance balance and Aβ neurotoxicity: A potential therapeutic molecule for Alzheimer's disease

Y Li, J Zhang, J Wan, A Liu, J Sun - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Alzheimer's disease (AD) is an age-related neurodegenerative disease with multiple
predisposing factors and complicated pathogenesis. Aβ peptide is one of the most important …

Protective effects of Indian spice curcumin against amyloid-β in Alzheimer's disease

PH Reddy, M Manczak, X Yin… - Journal of …, 2018 - content.iospress.com
The purpose of our article is to assess the current understanding of Indian spice, curcumin,
against amyloid-ß (Aß)-induced toxicity in Alzheimer's disease (AD) pathogenesis. Natural …

Melatonin: clinical perspectives in neurodegeneration

DP Cardinali - Frontiers in endocrinology, 2019 - frontiersin.org
Prevention of neurodegenerative diseases is presently a major goal for our Society and
melatonin, an unusual phylogenetically conserved molecule present in all aerobic …

Mechanism of oxidative stress and synapse dysfunction in the pathogenesis of Alzheimer's disease: understanding the therapeutics strategies

PK Kamat, A Kalani, S Rai, S Swarnkar, S Tota… - Molecular …, 2016 - Springer
Synapses are formed by interneuronal connections that permit a neuronal cell to pass an
electrical or chemical signal to another cell. This passage usually gets damaged or lost in …