Background: It is necessary to seek alternative therapies for depression, because side
effects of medications lead to poor adherence and some patients do not achieve a clinical …

Background: The Canadian Network for Mood and Anxiety Treatments (CANMAT)
conducted a revision of the 2009 guidelines by updating the evidence and …

Objective To systematically review evidence on the efficacy and safety of sleep deprivation
(SD) as a treatment option for patients with unipolar or bipolar depression. Methods A …

Sleep deprivation, alone or in combination with pharmacological treatment and as part of a
chronotherapy package, is of potential use for people with major depressive episodes …

Scientific evidence that circadian rhythms affect pharmacokinetics and pharmacodynamics
has highlighted the importance of drug dosing-time. Circadian oscillations alter drug …

Background Chronotherapy (sleep deprivation, sleep phase shifting and/or the use of bright
light) combines non-invasive and non-pharmacological interventions that may act rapidly …

Mood disorders (MDs) are chronic, recurrent mental diseases that affect millions of
individuals worldwide. Although the biogenic amine model has provided some clinical utility …

Objective: Bright light therapy (BLT) has recently come into increasing focus in the treatment
of adolescent depression, whereby light glasses today appear to be more feasible than light …

Introduction: The hypothalamic-pituitary-adrenal axis function in depression has been the
subject of considerable interest, and its function has been tested with a variety of methods …

The stable and persisting preference for activities in the late evening (ie eveningness) is
associated with a higher risk for depression, suicidality, and non-remission in major …