The kidneys are essential organs that filter the blood, removing urinary waste while
maintaining fluid and electrolyte homeostasis. Current conventional research models such …

Mammalian cells stably maintain high levels of DNA methylation despite expressing both
positive (DNMT3A/B) and negative (TET1-3) regulators. Here, we analyzed the independent …

Over the last 15 years connections between cell cycle control, maintenance of pluripotency,
and control of cell fate decisions have been firmly established. With the emergence of …

Abstract Background Haematopoietic stem cells (HSCs) first arise during development in the
aorta-gonad-mesonephros (AGM) region of the embryo from a population of haemogenic …

A progenitor cell could generate a certain type or multiple types of descendant cells during
embryonic development. To make all the descendant cell types and developmental …

Embryonic axis formation is essential for patterning and morphogenesis in vertebrates and
is tightly regulated by the dorsal organizer. Previously, we demonstrated that maternally …

Pericytes (PCs) are a type of perivascular cells that surround endothelial cells of small blood
vessels. In the brain, PCs show heterogeneity depending on their position within the …

Drug-induced cardiotoxicity reduces the success rates of drug development. Thus, the
limitations of current evaluation methods must be addressed. Human cardiac organoids …

Kidney organoid technology has led to a renaissance in kidney developmental biology. The
complex underpinnings of mammalian kidney development have provided a framework for …

Methods that predict fate potential or degree of differentiation from transcriptomic data have
identified rare progenitor populations and uncovered developmental regulatory …