Experimental and real-world evidence supporting the computational repurposing of bumetanide for APOE4-related Alzheimer's disease
The evident genetic, pathological and clinical heterogeneity of Alzheimer's disease (AD)
poses challenges for traditional drug development. We conducted a computational drug …
poses challenges for traditional drug development. We conducted a computational drug …
Navigating the complexities of drug development for inflammatory bowel disease
Inflammatory bowel disease (IBD)—consisting of ulcerative colitis and Crohn's disease—is a
complex, heterogeneous, immune-mediated inflammatory condition with a multifactorial …
complex, heterogeneous, immune-mediated inflammatory condition with a multifactorial …
Using a novel computational drug-repositioning approach (DrugPredict) to rapidly identify potent drug candidates for cancer treatment
Computation-based drug-repurposing/repositioning approaches can greatly speed up the
traditional drug discovery process. To date, systematic and comprehensive computation …
traditional drug discovery process. To date, systematic and comprehensive computation …
[HTML][HTML] Drug repurposing for glioblastoma based on molecular subtypes
A recent multi-platform analysis by The Cancer Genome Atlas identified four distinct
molecular subtypes for glioblastoma (GBM) and demonstrated that the subtypes correlate …
molecular subtypes for glioblastoma (GBM) and demonstrated that the subtypes correlate …
[HTML][HTML] Computational drug repurposing for inflammatory bowel disease using genetic information
L Grenier, P Hu - Computational and structural biotechnology journal, 2019 - Elsevier
As knowledge of the genetics behind inflammatory bowel disease (IBD) has continually
improved, there has been a demand for methods that can use this data in a clinically …
improved, there has been a demand for methods that can use this data in a clinically …
[HTML][HTML] Systems biology in inflammatory bowel diseases: on the way to precision medicine
Inflammatory bowel diseases (IBD) are chronic and recurrent inflammatory disorders of the
gastrointestinal tract. The elucidation of their etiopathology requires complex and multiple …
gastrointestinal tract. The elucidation of their etiopathology requires complex and multiple …
[HTML][HTML] Disease comorbidity-guided drug repositioning: a case study in schizophrenia
QQ Wang, R Xu - AMIA Annual Symposium Proceedings, 2018 - ncbi.nlm.nih.gov
The key to any computational drug repositioning is the availability of relevant data in
machine-understandable format. While large amount of genetic, genomic and chemical data …
machine-understandable format. While large amount of genetic, genomic and chemical data …
Experimental and real-world evidence supporting the computational repurposing of bumetanide for APOE4-related Alzheimer's disease
The evident genetic, pathological, and clinical heterogeneity of Alzheimer's disease (AD)
poses challenges for traditional drug development. We conducted a computational drug …
poses challenges for traditional drug development. We conducted a computational drug …
[图书][B] Integrated Computational Drug Discovery Approaches for Neuropsychiatric Disorders
M Zhou - 2020 - search.proquest.com
Neuropsychiatric disorders (NPDs) such as Alzheimer's disease (AD) lead to enormous
societal burdens. Current treatments of NPDs have limitations, and the drug development …
societal burdens. Current treatments of NPDs have limitations, and the drug development …
Methods for treating apoe4/4-associated disorders
WO2019200342A1 - Methods for treating apoe4/4-associated disorders - Google Patents
WO2019200342A1 - Methods for treating apoe4/4-associated disorders - Google Patents …
WO2019200342A1 - Methods for treating apoe4/4-associated disorders - Google Patents …