Runt-related transcription factor 2 (Runx2) is a fundamental transcription factor for bone
development. In endochondral ossification, Runx2 induces chondrocyte maturation …

Skeletal elements have a diverse range of shapes and sizes specialized to their various
roles including protecting internal organs, locomotion, feeding, hearing, and vocalization …

ABSTRACT RUNX transcription factors orchestrate many different aspects of biology,
including basic cellular and developmental processes, stem cell biology and tumorigenesis …

Abstract Semaphorin 3A (Sema3A) is a diffusible axonal chemorepellent that has an
important role in axon guidance,,,,. Previous studies have demonstrated that Sema3a …

Abstract Runt-related transcription factor-1 (Runx1) is required for chondrocyte-to-osteoblast
lineage commitment by enhancing both chondrogenesis and osteogenesis during …

Runx1 is highly expressed in osteoblasts, however, its function in osteogenesis is unclear.
We generated mesenchymal progenitor-specific (Runx1 f/f Twist2-Cre) and osteoblast …

Runx2 is the most upstream transcription factor essential for osteoblast differentiation. It
regulates the expression of Sp7, the protein of which is a crucial transcription factor for …

Runt-related transcription factor 1 (Runx1) plays a key role in cartilage formation, but its
function in articular cartilage formation is unclear. We generated non-inducible and …

A milestone in the evolutionary emergence of vertebrates was the invention of cartilage, a
tissue that has key roles in modeling, protecting and complementing the bony skeleton …

The Runt-related transcription factor (Runx) family plays various roles in the homeostasis of
cartilage. Here, we examined the role of Runx2 and Runx3 for osteoarthritis development in …