GABAA receptors: subtypes provide diversity of function and pharmacology

RW Olsen, W Sieghart - Neuropharmacology, 2009 - Elsevier
This mini-review attempts to update experimental evidence on the existence of GABAA
receptor pharmacological subtypes and to produce a list of those native receptors that exist …

[HTML][HTML] Patterns of mRNA and protein expression for 12 GABAA receptor subunits in the mouse brain

H Hörtnagl, RO Tasan, A Wieselthaler, E Kirchmair… - Neuroscience, 2013 - Elsevier
The GABAA receptor is the main inhibitory receptor in the brain and its subunits originate
from different genes or gene families (α1–α6, β1–β3, γ1–γ3, δ, ε, θ, π, or ρ1–3). In the mouse …

GABAA receptor diversity and pharmacology

H Möhler - Cell and tissue research, 2006 - Springer
Because of its control of spike-timing and oscillatory network activity, γ-aminobutyric acid
(GABA)-ergic inhibition is a key element in the central regulation of somatic and mental …

GABA receptors: pharmacological potential and pitfalls

M Jazvinscak Jembrek, J Vlainic - Current pharmaceutical …, 2015 - ingentaconnect.com
Gamma-amino butyric acid (GABA), the major inhibitory neurotransmitter in the mammalian
central nervous system, plays a key role in the regulation of neuronal transmission …

Alcohol-induced motor impairment caused by increased extrasynaptic GABAA receptor activity

HJ Hanchar, PD Dodson, RW Olsen, TS Otis… - Nature …, 2005 - nature.com
Neuronal mechanisms underlying alcohol intoxication are unclear. We find that alcohol
impairs motor coordination by enhancing tonic inhibition mediated by a specific subtype of …

A new naturally occurring GABAA receptor subunit partnership with high sensitivity to ethanol

J Glykys, Z Peng, D Chandra, GE Homanics… - Nature …, 2007 - nature.com
According to the rules of GABAA receptor (GABAAR) subunit assembly, α4 and α6 subunits
are considered to be the natural partners of δ subunits. These GABAARs are a preferred …

Treatment options in alzheimer s disease: the GABA story

M Solas, E Puerta, MJ Ramirez - Current pharmaceutical …, 2015 - ingentaconnect.com
Alzheimer's disease (AD) is the most common form of dementia in the elderly. Research
focused on identifying compounds that restore cognition and memory in AD patients is a …

Ethanol modulation of GABAergic transmission: the view from the slice

JL Weiner, CF Valenzuela - Pharmacology & therapeutics, 2006 - Elsevier
For almost three decades now, the GABAergic synapse has been the focus of intense study
for its putative role in mediating many of the behavioral consequences associated with acute …

Alcohol enhances GABAergic transmission to cerebellar granule cells via an increase in Golgi cell excitability

M Carta, M Mameli, CF Valenzuela - Journal of Neuroscience, 2004 - Soc Neuroscience
Alcohol intoxication alters coordination and motor skills, and this is responsible for a
significant number of traffic accident-related deaths around the world. Although the precise …

Quantitative localisation of synaptic and extrasynaptic GABAA receptor subunits on hippocampal pyramidal cells by freeze‐fracture replica immunolabelling

Y Kasugai, JD Swinny, JDB Roberts… - European Journal of …, 2010 - Wiley Online Library
Hippocampal CA1 pyramidal cells, which receive γ‐aminobutyric acid (GABA) ergic input
from at least 18 types of presynaptic neuron, express 14 subunits of the pentameric GABAA …