Mouse embryonic stem (ES) cells perpetuate in vitro the broad developmental potential of
naïve founder cells in the preimplantation embryo. ES cells self-renew relentlessly in culture …

Some coronavirus disease 2019 (COVID-19) patients develop acute pneumonia which can
result in a cytokine storm syndrome in response to Severe Acute Respiratory Syndrome …

Immunoediting sculpts immunogenicity and thwarts host anti-tumor responses in tumor cells
during tumorigenesis; however, it remains unknown whether metabolic programming of …

Cancer response to immunotherapy depends on the infiltration of CD8+ T cells and the
presence of tumor-associated macrophages within tumors. Still, little is known about the …

Weight loss is diagnostic of cachexia, a debilitating syndrome contributing mightily to
morbidity and mortality in cancer. Most research has probed mechanisms leading to muscle …

Background The insulin/IGF-1 signaling pathway has a major role in the regulation of
longevity both in Caenorhabditis elegans and mammalian species, ie, reduced activity of …

Self‐renewal of pluripotent mouse embryonic stem (ES) cells is sustained by the cytokine
leukaemia inhibitory factor (LIF) acting through the transcription factor Stat3. Several targets …

The incidence of cancer is continuing to rise and risk-tailored early diagnostic and/or primary
prevention strategies are urgently required. The ideal risk-predictive test should: integrate …

Transcription factor Stat 3 directs self‐renewal of pluripotent mouse embryonic stem (ES)
cells downstream of the cytokine leukemia inhibitory factor (LIF). Stat 3 upregulates pivotal …

Transcription factors are master regulators of various cellular processes under diverse
physiological and pathological conditions. Many transcription factors that are differentially …