Pyroptosis and necroptosis represent two pathways of genetically encoded necrotic cell
death. Although these cell death programmes can protect the host against microbial …

Cytokine dysregulation is believed to play a key role in the remodeling of the immune
system at older age, with evidence pointing to an inability to fine-control systemic …

Rationale: Atherosclerotic lesions are known for their cellular heterogeneity, yet the
molecular complexity within the cells of human plaques has not been fully assessed …

Patients with well-controlled LDL (low-density lipoprotein) levels still have residual
cardiovascular risk associated with elevated triglycerides. Epidemiological studies have …

Almost all human diseases are strongly associated with inflammation, and a deep
understanding of the exact mechanism is helpful for treatment. The NLRP3 inflammasome …

Atherosclerosis is one type of cardiovascular disease (CVD) in which activation of the
NLRP3 inflammasome and toll-like receptor (TLR) pathways is implicated. One of the most …

Cigarette smoking is a major risk factor for atherosclerosis and other cardiovascular
diseases. Increasing evidence has demonstrated that nicotine impairs the cardiovascular …

Chronic low-grade inflammation is a recognized key feature associated with type 2 diabetes
mellitus (T2DM) and its complications. In prospective randomized trials, sodium-glucose …

Nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3
(NLRP3) is an intracellular innate immune receptor that recognizes a diverse range of …

The pathophysiology of sepsis is extremely complex. During this disease, the exacerbation
of the inflammatory response causes oxidative stress, alterations in mitochondrial energy …