Neurodegenerative disorders are characterized by progressive loss of particular populations
of neurons. Apoptosis has been implicated in the pathogenesis of neurodegenerative …

Diabetic nephropathy is a common complication of type I and type II diabetes, in which renal
glomeruli are destroyed, resulting in renal damage, proteinuria, and hypertension …

Parkinson's disease is one of the most common neurodegenerative diseases in the elderly.
The motor symptoms occur predominantly due to substantial dopamine depletion, caused by …

Aim. This study was aimed at investigating the effects and molecular mechanisms of
physical activity intervention on Parkinson's disease (PD) and providing theoretical …

Diabetic kidney disease (DKD) is the main cause of end-stage renal disease, and its clinical
manifestations are progressive proteinuria, decreased glomerular filtration rate, and renal …

Apoptosis, autophagy and necrosis are the three main types of programmed cell death. One
or more of these types of programmed cell death may take place in neurons leading to their …

Objective Degenerative cerebellar ataxias (DCAs) affect up to 1 in 5,000 people worldwide,
leading to incoordination, tremor, and falls. Loss of Purkinje cells, nearly universal across …

Diabetic foot ulcer, is a chronic complication afflicting individuals with diabetes, continue to
increase worldwide, immensely burdening society. Programmed cell death, which includes …

The shaker rat carries a naturally occurring mutation leading to progressive ataxia
characterized by Purkinje cell (PC) loss. We previously reported on fine-mapping the shaker …

Cerebellar Purkinje cell (PC) death has been shown to occur in essential tremor, ataxia, and
many other neurodegenerative diseases in humans. Shaker mutant rats have an X-linked …