Organoids are three-dimensional (3D) miniature structures cultured in vitro produced from
either human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) derived from …

Organoids are three‐dimensional (3D) miniaturized versions of organs or tissues that are
derived from cells with stem potential and can self‐organize and differentiate into 3D cell …

Organoids and cells in organ‐on‐chip platforms replicate higher‐level anatomical,
physiological, or pathological states of tissues and organs. These technologies are widely …

Major depressive disorder with suicide behavior (sMDD) is a severe mood disorder, bringing
tremendous burden to family and society. Although reduced gamma amino butyric acid …

Intellectual disability and autism spectrum disorder (ASD) are common, and genetic testing
is increasingly performed in individuals with these diagnoses to inform prognosis, refine …

Understanding of human brain development, dysfunction and neurological diseases has
remained limited and challenging due to inability to recapitulate human brain-specific …

At the level of in vitro drug screening, the development of a phenotypic analysis system with
high-content screening at the core provides a strong platform to support high-throughput …

Induced pluripotent stem cells (iPSCs) are valuable in disease modeling because of their
potential to expand and differentiate into virtually any cell type and recapitulate key aspects …

There is an urgent need for predictive in vitro models to improve disease modeling and drug
target identification and validation, especially for neurological disorders. Cerebral …

Studying the etiology of human neurodevelopmental diseases has long been a challenging
task due to the brain's complexity and its limited accessibility. Human pluripotent stem cells …