NADPH oxidases (NOX): an overview from discovery, molecular mechanisms to physiology and pathology
The reactive oxygen species (ROS)-producing enzyme NADPH oxidase (NOX) was first
identified in the membrane of phagocytic cells. For many years, its only known role was in …
identified in the membrane of phagocytic cells. For many years, its only known role was in …
Parkinson's disease: Mechanisms, translational models and management strategies
C Raza, R Anjum - Life sciences, 2019 - Elsevier
Parkinson's disease is a progressive neurodegenerative disorder. The classical motor
symptoms include resting tremors, bradykinesia, rigidity and postural instability and are …
symptoms include resting tremors, bradykinesia, rigidity and postural instability and are …
Alpha-synuclein: Pathology, mitochondrial dysfunction and neuroinflammation in Parkinson's disease
Parkinson's disease (PD) is a complex, chronic and progressive neurodegenerative
disease. While the etiology of PD is likely multifactorial, the protein α-synuclein is a central …
disease. While the etiology of PD is likely multifactorial, the protein α-synuclein is a central …
The role of mitochondria in neurodegenerative diseases: the lesson from Alzheimer's disease and Parkinson's disease
G Monzio Compagnoni, A Di Fonzo, S Corti… - Molecular …, 2020 - Springer
Although the pathogenesis of neurodegenerative diseases is still widely unclear, various
mechanisms have been proposed and several pieces of evidence are supportive for an …
mechanisms have been proposed and several pieces of evidence are supportive for an …
Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential treatments
P Maiti, J Manna, GL Dunbar - Translational neurodegeneration, 2017 - Springer
Gradual degeneration and loss of dopaminergic neurons in the substantia nigra, pars
compacta and subsequent reduction of dopamine levels in striatum are associated with …
compacta and subsequent reduction of dopamine levels in striatum are associated with …
Mitochondrial dysfunction in Parkinson's disease–a key disease hallmark with therapeutic potential
MT Henrich, WH Oertel, DJ Surmeier… - Molecular …, 2023 - Springer
Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic
Parkinson's disease (PD). However, strategies aimed at ameliorating mitochondrial …
Parkinson's disease (PD). However, strategies aimed at ameliorating mitochondrial …
[HTML][HTML] MPTP-induced mouse model of Parkinson's disease: A promising direction for therapeutic strategies
M Mustapha, CNM Taib - Bosnian journal of basic medical …, 2021 - ncbi.nlm.nih.gov
Among the popular animal models of Parkinson's disease (PD) commonly used in research
are those that employ neurotoxins, especially 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine …
are those that employ neurotoxins, especially 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine …
A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids
H Renner, M Grabos, KJ Becker, TE Kagermeier, J Wu… - elife, 2020 - elifesciences.org
Three-dimensional (3D) culture systems have fueled hopes to bring about the next
generation of more physiologically relevant high-throughput screens (HTS). However …
generation of more physiologically relevant high-throughput screens (HTS). However …
Mitochondrial DNA damage and reactive oxygen species in neurodegenerative disease
N Nissanka, CT Moraes - FEBS letters, 2018 - Wiley Online Library
Mitochondria are essential organelles within the cell where most ATP is produced through
oxidative phosphorylation (OXPHOS). A subset of the genes needed for this process are …
oxidative phosphorylation (OXPHOS). A subset of the genes needed for this process are …
Conductive metal–organic framework microelectrodes regulated by conjugated molecular wires for monitoring of dopamine in the mouse brain
Y Wang, Y Qian, L Zhang, Z Zhang… - Journal of the …, 2023 - ACS Publications
Herein, we demonstrated a strategy to regulate the conductive metal–organic framework
(MOF) surface, by the conjugated molecule wires for selective and sensitive determination of …
(MOF) surface, by the conjugated molecule wires for selective and sensitive determination of …