Malignant disease occurs when neoplastic cells abandon their primary site of accretion,
cross tissue boundaries and penetrate the vasculature to colonize distant sites. This process …

This review summarizes the functional aspects, cellular kinetics and molecular mechanisms
related to liver regeneration. Liver regeneration is a model of regenerative growth of tissues …

The c-MET receptor is a receptor tyrosine kinase (RTK) that plays essential roles in normal
cell development and motility. Aberrant activation of c-MET can lead to both tumors growth …

Angiogenesis is thought to depend on a precise balance of positive and negative regulation.
Angiopoietin-1 (Ang1) is an angiogenic factor that signals through the endothelial cell …

On the basis of x-ray diffraction data to a resolution of 2.9 angstroms, atomic models of most
protein components of the bovine cytochrome bc1 complex were built, including core 1, core …

The Met tyrosine kinase receptor and its ligand, hepatocyte growth factor (HGF), play
important roles in normal development and in tumor growth and metastasis. HGF …

Death receptors such as Fas are present in a variety of organs including liver and play an
important role in homeostasis. What prevents these harmful receptors from forming …

SMAD proteins mediate signals from receptor serine–threonine kinases (RSKs) of the TGF-β
superfamily. We demonstrate here that HGF and EGF, which signal through RTKs, can also …

The hepatocyte growth factor (HGF/SF) receptor, Met, regulates mitogenesis, motility, and
morphogenesis in a cell type-dependent fashion. Activation of Met via autocrine, paracrine …

Embedding of cell-surface receptors into a membrane defines their dynamics but also
complicates experimental characterization of their signaling complexes. The hepatocyte …