Abstract Epidermal Growth Factor Receptor (EGFR) enacts major roles in the maintenance
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …

Aberrant signalling of ERBB family members plays an important role in tumorigenesis and in
the escape from antitumour immunity in multiple malignancies. Molecular-targeted agents …

The liver is the commonest site of metastatic disease for patients with colorectal cancer, with
at least 25% developing colorectal liver metastases (CRLM) during the course of their …

The ErbB receptor family, also known as the EGF receptor family or type I receptor family,
includes the epidermal growth factor (EGF) receptor (EGFR) or ErbB1/Her1, ErbB2/Her2 …

Breast cancer affects approximately 1 in 8 women, and it is estimated that over 246,660
women in the USA will be diagnosed with breast cancer in 2016. Breast cancer mortality has …

The epidermal growth factor receptor (EGFR) belongs to the tyrosine kinase receptors family
and is present in the epithelial cell membrane. Its endogenous activation occurs through the …

The ERBB family of receptor tyrosine kinases has a central role in the tumorigenesis of many
types of solid tumour. Various therapeutics targeting these receptors have been approved …

Lung cancers are characterised by abundant genetic diversity with relatively few recurrent
mutations occurring at high frequency. However, the genetic alterations often affect a …

The year 2007 marks exactly two decades since Human Epidermal Growth Factor Receptor-
2 (HER2) was functionally implicated in the pathogenesis of human breast cancer. This …

Objectives Epidermal growth factor plays a critical role in breast malignancies by enhancing
cell proliferation, invasion, angiogenesis and metastasis. Epithelial–mesenchymal transition …