Abstract Background Clostridioides (Clostridium) difficile is an important pathogen of
healthcare-associated diarrhea, however, an increase in the occurrence of C. difficile …

Oral antibiotics such as metronidazole, vancomycin and fidaxomicin are therapies of choice
for Clostridium difficile infection. Several important mechanisms for C. difficile antibiotic …

Clostridium difficile epidemiology has changed in recent years, with the emergence of highly
virulent types associated with severe infections, high rates of recurrences and mortality …

Metronidazole was until recently used as a first-line treatment for potentially life-threatening
Clostridioides difficile (CD) infection. Although cases of metronidazole resistance have been …

The incidence and mortality rate of Clostridium difficile infection have increased remarkably
in both hospital and community settings during the last two decades. The growth of infection …

Background Clostridioides difficile infection (CDI) is a leading cause of hospital-associated
antibiotic-related diarrhea and deaths worldwide. Vancomycin is one of the few antibiotics …

Clostridium difficile (C. difficile) is the most prevalent causative pathogen of healthcare‐
associated diarrhea. Notably, over the past 10 years, the number of Clostridium difficile …

Background Clostridium difficile is the leading cause of infectious diarrhea that develops in
patients after hospitalization during antibiotic administration. It has also become a big issue …

Antibiotic-associated diarrhea (AAD) is defined as diarrhea associated with antibiotic
exposure, either while on antibiotics, or for up to 8 weeks after antibiotic discontinuation. 1, 2 …

The rapid evolution of antibiotic resistance in Clostridium difficile and the consequent effects
on prevention and treatment of C. difficile infections (CDIs) are matter of concern for public …