The prevention of perioperative neurocognitive disorders is a priority for patients, families,
clinicians, and researchers. Given the multiple risk factors present throughout the …

Common human experience is that a long period without sleep is unsustainable, and it is
also detrimental to health and behavior. The powerful and primal urge to sleep after sleep …

Background The delirium-sparing effect of nighttime dexmedetomidine has not been studied
after surgery. We hypothesised that a nighttime dose of dexmedetomidine would reduce the …

While people 65 years of age and older represent 16% of the population in the United
States, they account for> 40% of surgical procedures performed each year. Maintaining …

Dexmedetomidine, a highly selective α2-adrenoceptor agonist, has sedative, anxiolytic,
analgesic, sympatholytic, and opioid-sparing properties and induces a unique sedative …

In this article, we conduct a systematic review of the literature to explore the specific role of
dexmedetomidine (DEX) on postoperative sleep and its associated mechanisms at present …

Long-term memories are formed by creating stable memory representations via memory
consolidation, which mainly occurs during sleep following the encoding of labile memories …

The lateral preoptic (LPO) hypothalamus is a center for NREM and REM sleep induction and
NREM sleep homeostasis. Although LPO is needed for NREM sleep, we found that calcium …

Sleep oscillations in the neocortex and hippocampus are critical for the integration of new
memories into stable generalized representations in neocortex. However, the role of the …

Background Enhanced recovery after surgery (ERAS) is now widely used in various surgical
fields including gynecological laparoscopic surgery, but the advantages of opioid-free …