Acid-sensing ion channels in pain and disease
Why do neurons sense extracellular acid? In large part, this question has driven increasing
investigation on acid-sensing ion channels (ASICs) in the CNS and the peripheral nervous …
investigation on acid-sensing ion channels (ASICs) in the CNS and the peripheral nervous …
Calcium-permeable ion channels in pain signaling
The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …
dependent on a wide range of different types of voltage-and ligand-gated ion channels …
[HTML][HTML] The amygdala is a chemosensor that detects carbon dioxide and acidosis to elicit fear behavior
AE Ziemann, JE Allen, NS Dahdaleh, II Drebot… - Cell, 2009 - cell.com
The amygdala processes and directs inputs and outputs that are key to fear behavior.
However, whether it directly senses fear-evoking stimuli is unknown. Because the amygdala …
However, whether it directly senses fear-evoking stimuli is unknown. Because the amygdala …
Ion channels as therapeutic targets: a drug discovery perspective
SK Bagal, AD Brown, PJ Cox, K Omoto… - Journal of medicinal …, 2013 - ACS Publications
Ion channels are membrane proteins expressed in almost all living cells. The sequencing of
the human genome has identified more than 400 putative ion channels, but only a fraction of …
the human genome has identified more than 400 putative ion channels, but only a fraction of …
Acid-sensing ion channels: advances, questions and therapeutic opportunities
JA Wemmie, MP Price, MJ Welsh - Trends in neurosciences, 2006 - cell.com
Extracellular acid can have important effects on neuron function. In central and peripheral
neurons, acid-sensing ion channels (ASICs) have emerged as key receptors for extracellular …
neurons, acid-sensing ion channels (ASICs) have emerged as key receptors for extracellular …
ASIC3, a sensor of acidic and primary inflammatory pain
Acid‐sensing ion channels (ASICs) are cationic channels activated by extracellular acidosis
that are expressed in both central and peripheral nervous systems. Although peripheral …
that are expressed in both central and peripheral nervous systems. Although peripheral …
Acid-sensing ion channels (ASICs): pharmacology and implication in pain
Tissue acidosis is a common feature of many painful conditions. Protons are indeed among
the first factors released by injured tissues, inducing a local pH fall that depolarizes …
the first factors released by injured tissues, inducing a local pH fall that depolarizes …
The Concise Guide to PHARMACOLOGY 2013/14: ion channels
SPH Alexander, HE Benson… - British journal of …, 2013 - Wiley Online Library
Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …
International Union of Basic and Clinical Pharmacology. XCI. structure, function, and pharmacology of acid-sensing ion channels and the epithelial Na+ channel
S Kellenberger, L Schild - Pharmacological reviews, 2015 - ASPET
The epithelial Na+ channel (ENaC) and the acid-sensing ion channels (ASICs) form
subfamilies within the ENaC/degenerin family of Na+ channels. ENaC mediates …
subfamilies within the ENaC/degenerin family of Na+ channels. ENaC mediates …
Preclinical assessment of inflammatory pain
MM Muley, E Krustev… - CNS neuroscience & …, 2016 - Wiley Online Library
While acute inflammation is a natural physiological response to tissue injury or infection,
chronic inflammation is maladaptive and engenders a considerable amount of adverse pain …
chronic inflammation is maladaptive and engenders a considerable amount of adverse pain …