Macrolides are a diverse class of hydrophobic compounds characterized by a macrocyclic
lactone ring and distinguished by variable side chains/groups. Some of the most well …

Antibiotics have become a mainstay of healthcare in the past century due to their activity
against pathogens. This manuscript reviews the impact of antibiotic use on the intestinal …

Background Macrolides are a class of broad-spectrum antibiotics of large molecular size.
The class includes erythromycin, clarithromycin, and azithromycin, among others 1 …

The solubility properties of tinidazole (TNZ) in investigated fourteen mono-solvents were
further studied at several temperature points (278.15 K∼ 323.15 K) under 101.2 kPa using …

While the relevance of inter-ethnic differences to the pharmacokinetic variabilities of
antimicrobials has been reported in studies recruiting healthy subjects, differences in …

Cefiderocol is a new siderophore-cephalosporin for the treatment of multi-drug resistant
Gram-negative pathogens. As a reserve agent, it will and should be used primarily in …

Currently there are no pharmacokinetic (PK) data to guide antibiotic dosing in critically ill
Australian Indigenous patients with severe sepsis. This study aimed to determine whether …

Introduction: Linezolid is an oxazolidinone antibiotic active against Gram-positive bacteria,
and is most commonly used to treat life-threatening infections in critically ill patients. The …

Limited studies have investigated population pharmacokinetic (PK) models and optimal
dosage regimens of meropenem for critically ill adult patients using the probability of target …

Importance Prior publications have reported the sporadic development of sensorineural
hearing loss (SNHL) after intravenous or high-dose macrolide therapy for adults with …