Expression and function of the epidermal growth factor receptor in physiology and disease

J Chen, F Zeng, SJ Forrester, S Eguchi… - Physiological …, 2016 - journals.physiology.org
The epidermal growth factor receptor (EGFR) is the prototypical member of a family of
membrane-associated intrinsic tyrosine kinase receptors, the ErbB family. EGFR is activated …

Nuclear EGFR as a molecular target in cancer

TM Brand, M Iida, N Luthar, MM Starr… - Radiotherapy and …, 2013 - Elsevier
The epidermal growth factor receptor (EGFR) has been one of the most targeted receptors in
the field of oncology. While anti-EGFR inhibitors have demonstrated clinical success in …

Blocking c-Met–mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors

Y Du, H Yamaguchi, Y Wei, JL Hsu, HL Wang… - Nature medicine, 2016 - nature.com
Abstract Poly (ADP-ribose) polymerase (PARP) inhibitors have emerged as promising
therapeutics for many diseases, including cancer, in clinical trials. One PARP inhibitor …

The paradoxical functions of EGFR during breast cancer progression

R Ali, MK Wendt - Signal transduction and targeted therapy, 2017 - nature.com
The epidermal growth factor receptor (EGFR) is one of the most well-studied signaling
pathways in cancer progression. As a result, numerous therapeutics including small …

The mysterious ways of ErbB2/HER2 trafficking

V Bertelsen, E Stang - Membranes, 2014 - mdpi.com
The EGFR-or ErbB-family of receptor tyrosine kinases consists of EGFR/ErbB1,
ErbB2/HER2, ErbB3/HER3 and ErbB4/HER4. Receptor activation and downstream …

Regulation of sister chromatid cohesion by nuclear PD-L1

J Yu, B Qin, AM Moyer, S Nowsheen, X Tu, H Dong… - Cell research, 2020 - nature.com
Abstract Programmed death ligand-1 (PD-L1 or B7-H1) is well known for its role in immune
checkpoint regulation, but its function inside the tumor cells has rarely been explored. Here …

The role of the NDRG1 in the pathogenesis and treatment of breast cancer

X Zhao, DR Richardson - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
Breast cancer (BC) is the leading cause of cancer death in women. This disease is
heterogeneous, with clinical subtypes being estrogen receptor-α (ER-α) positive, having …

Biological functions of connexin43 beyond intercellular communication

T Martins-Marques, T Ribeiro-Rodrigues… - Trends in cell …, 2019 - cell.com
Connexin43 (Cx43) is commonly associated with direct cell–cell communication through
gap junctions (GJs). However, recent groundbreaking studies have challenged this dogma …

Receptor tyrosine kinases in the nucleus

G Carpenter, HJ Liao - Cold Spring Harbor perspectives …, 2013 - cshperspectives.cshlp.org
To date, 18 distinct receptor tyrosine kinases (RTKs) are reported to be trafficked from the
cell surface to the nucleus in response to ligand binding or heterologous agonist exposure …

Proteolytic cleavage, trafficking, and functions of nuclear receptor tyrosine kinases

MK Chen, MC Hung - The FEBS journal, 2015 - Wiley Online Library
Intracellular localization has been reported for over three‐quarters of receptor tyrosine
kinase (RTK) families in response to environmental stimuli. Internalized RTK may bind to …