Expression and function of the epidermal growth factor receptor in physiology and disease
J Chen, F Zeng, SJ Forrester, S Eguchi… - Physiological …, 2016 - journals.physiology.org
The epidermal growth factor receptor (EGFR) is the prototypical member of a family of
membrane-associated intrinsic tyrosine kinase receptors, the ErbB family. EGFR is activated …
membrane-associated intrinsic tyrosine kinase receptors, the ErbB family. EGFR is activated …
Nuclear EGFR as a molecular target in cancer
TM Brand, M Iida, N Luthar, MM Starr… - Radiotherapy and …, 2013 - Elsevier
The epidermal growth factor receptor (EGFR) has been one of the most targeted receptors in
the field of oncology. While anti-EGFR inhibitors have demonstrated clinical success in …
the field of oncology. While anti-EGFR inhibitors have demonstrated clinical success in …
Blocking c-Met–mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors
Y Du, H Yamaguchi, Y Wei, JL Hsu, HL Wang… - Nature medicine, 2016 - nature.com
Abstract Poly (ADP-ribose) polymerase (PARP) inhibitors have emerged as promising
therapeutics for many diseases, including cancer, in clinical trials. One PARP inhibitor …
therapeutics for many diseases, including cancer, in clinical trials. One PARP inhibitor …
The paradoxical functions of EGFR during breast cancer progression
R Ali, MK Wendt - Signal transduction and targeted therapy, 2017 - nature.com
The epidermal growth factor receptor (EGFR) is one of the most well-studied signaling
pathways in cancer progression. As a result, numerous therapeutics including small …
pathways in cancer progression. As a result, numerous therapeutics including small …
The mysterious ways of ErbB2/HER2 trafficking
V Bertelsen, E Stang - Membranes, 2014 - mdpi.com
The EGFR-or ErbB-family of receptor tyrosine kinases consists of EGFR/ErbB1,
ErbB2/HER2, ErbB3/HER3 and ErbB4/HER4. Receptor activation and downstream …
ErbB2/HER2, ErbB3/HER3 and ErbB4/HER4. Receptor activation and downstream …
Regulation of sister chromatid cohesion by nuclear PD-L1
Abstract Programmed death ligand-1 (PD-L1 or B7-H1) is well known for its role in immune
checkpoint regulation, but its function inside the tumor cells has rarely been explored. Here …
checkpoint regulation, but its function inside the tumor cells has rarely been explored. Here …
The role of the NDRG1 in the pathogenesis and treatment of breast cancer
X Zhao, DR Richardson - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
Breast cancer (BC) is the leading cause of cancer death in women. This disease is
heterogeneous, with clinical subtypes being estrogen receptor-α (ER-α) positive, having …
heterogeneous, with clinical subtypes being estrogen receptor-α (ER-α) positive, having …
Biological functions of connexin43 beyond intercellular communication
T Martins-Marques, T Ribeiro-Rodrigues… - Trends in cell …, 2019 - cell.com
Connexin43 (Cx43) is commonly associated with direct cell–cell communication through
gap junctions (GJs). However, recent groundbreaking studies have challenged this dogma …
gap junctions (GJs). However, recent groundbreaking studies have challenged this dogma …
Receptor tyrosine kinases in the nucleus
G Carpenter, HJ Liao - Cold Spring Harbor perspectives …, 2013 - cshperspectives.cshlp.org
To date, 18 distinct receptor tyrosine kinases (RTKs) are reported to be trafficked from the
cell surface to the nucleus in response to ligand binding or heterologous agonist exposure …
cell surface to the nucleus in response to ligand binding or heterologous agonist exposure …
Proteolytic cleavage, trafficking, and functions of nuclear receptor tyrosine kinases
Intracellular localization has been reported for over three‐quarters of receptor tyrosine
kinase (RTK) families in response to environmental stimuli. Internalized RTK may bind to …
kinase (RTK) families in response to environmental stimuli. Internalized RTK may bind to …