Molecular self-assembly plays a vital role in the nucleation process and sometimes
determines the nucleation outcomes. In this study, ultrasound technology was applied to …

Propose The propose is to investigate the reasons for the insolubility of Form III in water and
to explore the mechanism of the hydration process of Form III. Methods The conformational …

To gain insights into the effect of weak interactions in solvate formation and structure–
property correlation, experimental (thermal and structural analysis) and computational …

l-Histidine forms A and B usually crystallize simultaneously in pure aqueous solution, posing
a significant challenge in selectively obtaining one pure polymorph. In this study, we …

The nucleation in the p-hydroxybenzoic acid: glutaric acid 1: 1 cocrystal (PHBA: GLU)
system has been investigated in stoichiometric and non-stoichiometric acetonitrile solutions …

In this work, thermodynamic and kinetic factors that affect formation and phase
transformation process of different solid forms of levofloxacin hydrochloride were …

Understanding transformation pathway and mechanism in multiple-hydrates-system is
essential for controlling hydrate forms in the manufacture. In this work, the investigation of …

In this work, two anhydrates (form A and form B) and one dihydrate (form C) of aztreonam
were found and were characterized by powder X-ray diffraction (PXRD), thermogravimetric …

A case study highlighting the risk of generating undesired hydrate polymorph following
seeded distillative crystallization of an active pharmaceutical ingredient (API) from aqueous …

In this study, a robust continuous antisolvent crystallization method was developed to
produce the hydrate form of spironolactone. Continuous crystallizations were implemented …