Dendritic cells (DCs) develop in the bone marrow from haematopoietic progenitors that have
numerous shared characteristics between mice and humans. Human counterparts of mouse …

Steady-state hematopoietic stem cells'(HSCs) self-renewal and differentiation toward their
mature progeny in the adult bone marrow is tightly regulated by cues from the …

To understand stem cell differentiation along multiple lineages, it is necessary to resolve
heterogeneous cellular states and the ancestral relationships between them. We developed …

Although haematopoietic stem cells (HSCs) are commonly assumed to reside within a
specialized microenvironment, or niche, most published experimental manipulations of the …

Dendritic cells (DC) are currently classified as conventional DCs (cDCs) and plasmacytoid
DCs (pDCs). Through a combination of single-cell transcriptomic analysis, mass cytometry …

Enormous numbers of adult blood cells are constantly regenerated throughout life from
hematopoietic stem cells through a series of progenitor stages. Accessibility, robust …

T cells are the key mediators in cell-mediated immunity. Their development and maturation
involve a complex variety of interactions with nonlymphoid cell products and receptors …

Current clinical judgment in bladder cancer (BC) relies primarily on pathological stage and
grade. We investigated whether a molecular classification of tumor cell differentiation, based …

It is now established that the transcription factors E2A, EBF1 and Foxo1 have critical roles in
B cell development. Here we show that E2A and EBF1 bound regulatory elements present in …

An important risk in the clinical application of human pluripotent stem cells (hPSCs),
including human embryonic and induced pluripotent stem cells (hESCs and hiPSCs), is …