Multiple sclerosis (MS) is an autoimmune, inflammatory neurodegenerative disease of the
central nervous system characterized by demyelination and axonal damage. Diagnosis and …

Secondary progressive multiple sclerosis (SPMS) is the second most common form of
multiple sclerosis (MS). One in two relapse remitting multiple sclerosis (RRMS) patients will …

Objective: To investigate a potential effect of riluzole on serum neurofilaments (Nf) compared
to placebo and the relationship between longitudinal clinical and MRI outcomes and serum …

Background: Neurofilament light chain (NFL) is a cerebrospinal fluid (CSF) marker of
neuroaxonal damage in multiple sclerosis (MS). Objective: To determine the correlation of …

With the contribution from more than one hundred CNS neurotrauma experts, this book
provides a comprehensive and up-to-date account on the latest developments in the area of …

Background Acute demyelinating optic neuritis, a common feature of multiple sclerosis, can
damage vision through neurodegeneration in the optic nerve and in its fibres in the retina …

Background To allow early diagnosis and monitoring of disease progression, there is a need
for biomarkers in amyotrophic lateral sclerosis (ALS). Neurofilaments (NF) are emerging …

Background Neurofilament proteins have been extensively studied in relapsing–remitting
multiple sclerosis, where they are promising biomarkers of disease activity and treatment …

In contrast to other diseases that go along with spasticity (eg spinal cord injury), spasticity in
chronic autoimmune diseases involving the CNS is complicated by the ongoing damage of …

Objective Multiple sclerosis (MS) is associated with cognitive impairment (CI) such as
slowed information processing speed (IPS). Currently, no immunocellular or molecular …