Analytical ultracentrifugation (AUC) is a versatile and powerful method for the quantitative
analysis of macromolecules in solution. AUC has broad applications for the study of …

The use of nanotechnology in medical products has been demonstrated at laboratory scale,
and many resulting nanomedicines are in the translational phase toward clinical …

The analysis of analytical ultracentrifugation (AUC) data has been greatly facilitated by the
advances accumulated in recent years. These improvements include refinements in AUC …

Sedimentation velocity analytical ultracentrifugation is an important tool in the
characterization of macromolecules and nanoparticles in solution. The sedimentation …

Multisite interactions and the formation of ternary or higher‐order protein complexes are
ubiquitous features of protein interactions. Cooperativity between different ligands is a …

Modern computational strategies have allowed for the direct modeling of the sedimentation
process of heterogeneous mixtures, resulting in sedimentation velocity (SV) size‐distribution …

Transcription in eukaryotic genomes depends on enzymes that regulate the degree of
histone H3 lysine 4 (H3K4) methylation. The mixed lineage leukemia protein-1 (MLL1) is a …

We report a model-independent analysis approach for fitting sedimentation velocity data
which permits simultaneous determination of shape and molecular weight distributions for …

PPM1D encodes a serine/threonine phosphatase that regulates numerous pathways
including the DNA damage response and p53. Activating mutations and amplification of …

The mixed lineage leukemia protein-1 (MLL1) belongs to the SET1 family of histone H3
lysine 4 methyltransferases. Recent studies indicate that the catalytic subunits of SET1 …