Beetroot is rich in various bioactive phytochemicals, which are beneficial for human health
and exert protective effects against several disease conditions like cancer, atherosclerosis …

The hallmark symptom of chronic heart failure (HF) is severe exercise intolerance. Impaired
perfusive and diffusive O2 transport are two of the major determinants of reduced physical …

Three sentinel parameters of aerobic performance are the maximal oxygen uptake (), critical
power (CP) and speed of the kinetics following exercise onset. Of these, the latter is …

Rationale: Nitrate-rich beetroot juice has been shown to improve exercise capacity in heart
failure with preserved ejection fraction, but studies using pharmacological preparations of …

Although well documented drug therapies are available for the management of ventricular
hypertrophy (VH) and heart failure (HF), most patients nonetheless experience a downhill …

Endothelial dysfunction and reduced nitric oxide (NO) signaling are key abnormalities
leading to skeletal muscle oxygen delivery-utilization mismatch and poor physical capacity …

Nitrate (NO 3−) ingestion has been shown to have vasoactive and ergogenic effects that
have been attributed to increased nitric oxide (NO) production. Recent observations in …

Pulmonary hypertension (PH) is a chronic, progressive disease characterized by pulmonary
vascular remodelling, dyspnoea and exercise intolerance. Key facets of dyspnoea and …

Exercise intolerance is a primary symptom of heart failure (HF); however, the specific
contribution of central and peripheral factors to this intolerance is not well described. The …

Dietary nitrate supplementation has positive effects on mitochondrial and muscle contractile
efficiency during large muscle mass exercise in humans and on skeletal muscle blood flow …