Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes
Cells utilize diverse ATP-dependent nucleosome-remodelling complexes to carry out
histone sliding, ejection or the incorporation of histone variants, suggesting that different …
histone sliding, ejection or the incorporation of histone variants, suggesting that different …
Regulating the chromatin landscape: structural and mechanistic perspectives
B Bartholomew - Annual review of biochemistry, 2014 - annualreviews.org
A large family of chromatin remodelers that noncovalently modify chromatin is crucial in cell
development and differentiation. They are often the targets of cancer, neurological disorders …
development and differentiation. They are often the targets of cancer, neurological disorders …
Structure and regulation of the human INO80–nucleosome complex
R Ayala, O Willhoft, RJ Aramayo, M Wilkinson… - Nature, 2018 - nature.com
Access to DNA within nucleosomes is required for a variety of processes in cells including
transcription, replication and repair. Consequently, cells encode multiple systems that …
transcription, replication and repair. Consequently, cells encode multiple systems that …
Genome-wide nucleosome specificity and directionality of chromatin remodelers
K Yen, V Vinayachandran, K Batta, RT Koerber… - Cell, 2012 - cell.com
How chromatin remodelers cooperate to organize nucleosomes around the start and end of
genes is not known. We determined the genome-wide binding of remodeler complexes …
genes is not known. We determined the genome-wide binding of remodeler complexes …
[HTML][HTML] SWR-C and INO80 chromatin remodelers recognize nucleosome-free regions near+ 1 nucleosomes
K Yen, V Vinayachandran, BF Pugh - Cell, 2013 - cell.com
Summary SWR-C/SWR1 and INO80 are multisubunit complexes that catalyze the deposition
and removal, respectively, of histone variant H2A. Z from the first nucleosome at the start of …
and removal, respectively, of histone variant H2A. Z from the first nucleosome at the start of …
The chromodomains of the Chd1 chromatin remodeler regulate DNA access to the ATPase motor
G Hauk, JN McKnight, IM Nodelman, GD Bowman - Molecular cell, 2010 - cell.com
Chromatin remodelers are ATP-driven machines that assemble, slide, and remove
nucleosomes from DNA, but how the ATPase motors of remodelers are regulated is poorly …
nucleosomes from DNA, but how the ATPase motors of remodelers are regulated is poorly …
Regulation of ISWI involves inhibitory modules antagonized by nucleosomal epitopes
CR Clapier, BR Cairns - Nature, 2012 - nature.com
Chromatin-remodelling complexes (CRCs) mobilize nucleosomes to mediate the access of
DNA-binding factors to their sites in vivo. These CRCs contain a catalytic subunit that bears …
DNA-binding factors to their sites in vivo. These CRCs contain a catalytic subunit that bears …
Distortion of histone octamer core promotes nucleosome mobilization by a chromatin remodeler
INTRODUCTION The establishment of specific gene expression states during the course of
development, as well as their maintenance through the disruptive events of transcription …
development, as well as their maintenance through the disruptive events of transcription …
Cryo-EM structures of remodeler-nucleosome intermediates suggest allosteric control through the nucleosome
The SNF2h remodeler slides nucleosomes most efficiently as a dimer, yet how the two
protomers avoid a tug-of-war is unclear. Furthermore, SNF2h couples histone octamer …
protomers avoid a tug-of-war is unclear. Furthermore, SNF2h couples histone octamer …
The chromatin remodeller ACF acts as a dimeric motor to space nucleosomes
LR Racki, JG Yang, N Naber, PD Partensky, A Acevedo… - Nature, 2009 - nature.com
Evenly spaced nucleosomes directly correlate with condensed chromatin and gene
silencing. The ATP-dependent chromatin assembly factor (ACF) forms such structures in …
silencing. The ATP-dependent chromatin assembly factor (ACF) forms such structures in …