The DNA of each cell is wrapped around histone octamers, forming so-called 'nucleosomal
core particles'. These histone proteins have tails that project from the nucleosome and many …

Post-translational modification (PTM) in histone proteins is a covalent modification which
mainly consists of methylation, phosphorylation, acetylation, ubiquitylation, SUMOylation …

Since their discovery in the 1980s and 1990s, the human protein lysine acetyltransferase
encoded by the paralogous p300 and CBP genes has received much interest. p300/CBP …

The diversity of distinct covalent forms of proteins (the proteome) greatly exceeds the
number of proteins predicted by DNA coding capacities owing to directed posttranslational …

CpG island hypermethylation and global genomic hypomethylation are common epigenetic
features of cancer cells. Less attention has been focused on histone modifications in cancer …

Chromatin is the physiologically relevant substrate for all genetic processes inside the nuclei
of eukaryotic cells. Dynamic changes in the local and global organization of chromatin are …

A stable complex containing MLL1 and MOF has been immunoaffinity purified from a human
cell line that stably expresses an epitope-tagged WDR5 subunit. Stable interactions …

Male germ cell differentiation is a highly regulated multistep process initiated by the
commitment of progenitor cells into meiosis and characterized by major chromatin …

Histones undergo several different post-translational modifications that control a variety of
physiological processes. These covalent modifications show substantial cross-regulation …

Revised and updated, Chemical Reagents for Protein Modification, Third Edition is an
encyclopedic work describing the many approaches to the site-specific modification of …