Biological systems are composed of heterogeneous populations of cells that
intercommunicate to form a functional living tissue. Biological function varies greatly across …

Mass spectrometry (MS) imaging links molecular information and the spatial distribution of
analytes within a sample. In contrast to most histochemical techniques, mass spectrometry …

Formalin-fixed and paraffin-embedded (FFPE) tissue specimens are the gold standard for
histological examination, and they provide valuable molecular information in tissue-based …

MALDI mass spectrometry imaging is able to simultaneously determine the spatial
distribution of hundreds of molecules directly from tissue sections, without labeling and …

Paper spray mass spectrometry (PS-MS) is explored as a fast and convenient way for direct
analysis of molecules in tissues with minimum sample pretreatment. This technique allows …

In recent years, matrix-assisted laser desorption/ionization (MALDI)-imaging mass
spectrometry has become a mature technology, allowing for reproducible high-resolution …

A new tissue sample embedding and processing method is presented that provides
downstream compatibility with numerous different histological, molecular biology, and …

Rationale In mass spectrometry imaging (MSI) it is often desirable to analyse the same
sample in both polarities to extract the most information. However, many matrices that …

Mass spectrometric imaging (MSI) is an analytical technique used to determine the
distribution of individual analytes within a given sample. A wide array of analytes and …

This Feature focuses on a review of recent developments in mass spectrometry imaging
(MSI) of lipid isomers in biological tissues. The tandem MS techniques utilizing online and …