Mass spectrometry (MS) has become one of the key technologies of structural biology. In this
review, the contributions of chemical cross-linking combined with mass spectrometry (XL …

Proteins adopt different higher-order structures (HOS) to enable their unique biological
functions. Understanding the complexities of protein higher-order structures and dynamics …

Mass spectrometry is a central technology in the life sciences, providing our most
comprehensive account of the molecular inventory of the cell. In parallel with developments …

Biological membranes formed of amphipathic lipid bilayers provide chemical barriers to
separate cells from their external environments and define subcellular compartments …

The activation of G proteins by G protein-coupled receptors (GPCRs) underlies the majority
of transmembrane signaling by hormones and neurotransmitters. Recent structures of GPCR …

Membrane proteins that exist in lipid bilayers are not isolated molecular entities. The lipid
molecules that surround them play crucial roles in maintaining their full structural and …

Solution-phase hydrogen/deuterium exchange (HDX) coupled to mass spectrometry (MS) is
a widespread tool for structural analysis across academia and the biopharmaceutical …

Top-down mass spectrometry (MS) analyzes intact proteins at the proteoform level, which
allows researchers to better understand the functions of protein modifications. Recently, top …

Chemistry” on HDX MS. 1 That review covered HDX MS applications from January 2012
through June 2014 and described the publications in terms of sector, geography, and topic …

Mass spectrometry is well-established as one of the primary methods used to characterize
peptides and proteins. New advances in instrumentation and innovative analytical workflows …