Stem cell-based therapies for osteoarthritis: challenges and... : Current Opinion in
Rheumatology Stem cell-based therapies for osteoarthritis: challenges and opportunities …

Highlights•Cellular senescence drives age-related decline of the musculoskeletal
system.•The Senescence Associated Secretory Phenotype (SASP) can chronically impair …

Mesenchymal stem cells (MSCs) are being exploited in regenerative medicine due to their tri-
lineage differentiation and immunomodulation activity. Currently, there are two major …

Objective To assess whether synovial mesenchymal stem cells (SMSCs) from patients with
osteoarthritis (OA) or rheumatoid arthritis (RA) can be used as an alternative cell source for …

Background aims Previous studies have demonstrated that porcine synovial membrane
stem cells can adhere to a cartilage defect in vivo through the use of a tissue-engineered …

Osteoarthritis (OA) is a multifactorial, often progressive, painful disease. OA often progresses
with an apparent irreversible loss of articular cartilage, exposing underlying bone, resulting …

Healing of articular cartilage is a major clinical challenge as it also lacks a direct vasculature
and nerves, and carries a limited number of resident chondrocytes that do not proliferate …

Orthopedic implants including engineered bone tissue are commonly tested in sheep. To
avoid rejection of heterologous or xenogeneic cells, autologous cells are preferably used …

Post‐traumatic osteoarthritis (PTOA) development is often observed following traumatic
knee injuries involving key stabilising structures such as the cruciate ligaments or the …

Abstract Purpose of Review Recently, significant progress has been made in the research
related to regenerative medicine. At the same time, biomedical implants in orthopedics and …