Abstract α-Synuclein (α-Syn) has been extensively studied for its structural and biophysical
properties owing to its pathophysiological role in Parkinson's disease (PD). Lewy bodies …

Fluorescence resonance energy transfer (FRET) is a nonradiative process whereby an
excited state donor D (usually a fluorophore) transfers energy to a proximal ground state …

The protein α-synuclein is the main component of Lewy bodies, the neuron-associated
aggregates seen in Parkinson disease and other neurodegenerative pathologies. An 11 …

α-Synuclein accumulation and mitochondrial dysfunction have both been strongly implicated
in the pathogenesis of Parkinson's disease (PD), and the two appear to be related …

Aggregation of α‐synuclein (αS) is involved in the pathogenesis of Parkinson's disease (PD)
and a variety of related neurodegenerative disorders. The physiological function of αS is …

We studied the coupled binding and folding of α-synuclein, an intrinsically disordered
protein linked with Parkinson's disease. Using single-molecule fluorescence resonance …

The aggregation of α-synuclein (AS) is characteristic of Parkinson's disease and other
neurodegenerative synucleinopathies. Interactions with metal ions affect dramatically the …

The challenges associated with the structural characterization of disordered proteins have
resulted in the application of a host of biophysical methods to such systems. NMR …

Amyloidogenesis is a characteristic feature of the 40 or so known protein deposition
diseases, and accumulating evidence strongly suggests that self-association of misfolded …

Three familial variants of the presynaptic protein α-synuclein (αS), A30P, E46K, and A53T,
correlate with rare inherited Parkinson's disease (PD), while wild-type αS is implicated in …